Title:
INHIBITORS OF BETA-SECRETASE
Document Type and Number:
WIPO Patent Application WO/2013/134085
Kind Code:
A8
Abstract:
The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACEl) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.
Inventors:
BUKHTIYAROV YURI (US)
CACATIAN SALVACION (US)
DILLARD LAWRENCE WAYNE (US)
DORNER-CIOSSEK CORNELIA (DE)
FUCHS KLAUS (DE)
JIA LANQI (US)
LALA DEEPAK S (US)
MORALES-RAMOS ANGEL (US)
RAST GEORG (DE)
REEVES JONATHAN (US)
SINGH SURESH B (US)
VENKATRAMAN SHANKAR (US)
XU ZHENRONG (US)
YUAN JING (US)
ZHAO YI (US)
ZHENG YAJUN (US)
CACATIAN SALVACION (US)
DILLARD LAWRENCE WAYNE (US)
DORNER-CIOSSEK CORNELIA (DE)
FUCHS KLAUS (DE)
JIA LANQI (US)
LALA DEEPAK S (US)
MORALES-RAMOS ANGEL (US)
RAST GEORG (DE)
REEVES JONATHAN (US)
SINGH SURESH B (US)
VENKATRAMAN SHANKAR (US)
XU ZHENRONG (US)
YUAN JING (US)
ZHAO YI (US)
ZHENG YAJUN (US)
Application Number:
PCT/US2013/028796
Publication Date:
September 04, 2014
Filing Date:
March 04, 2013
Export Citation:
Assignee:
BOEHRINGER INGELHEIM INT (DE)
VITAE PHARMACEUTICALS INC (US)
VITAE PHARMACEUTICALS INC (US)
International Classes:
C07D235/02; A61K31/4184; A61P25/28; C07C49/323; C07D403/06; C07D407/06
Attorney, Agent or Firm:
DAVIS, Steven, G. et al. (LLP265 Franklin Stree, Boston MA, US)
Download PDF: