INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES

WIPO Patent Application WO2002083667

A3

The present invention provides compounds of formula (I): or a pharmaceutically acceptable derivative thereof, wherein A, B, Ra, R1, R2, R3 and R4 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved in cell proliferation, cell death and response to extracellular stimuli; Lck and Src kinase. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

CAO JINGRONG (US)
GREEN JEREMY (US)
MOON YOUNG-CHOON (US)
WANG JIAN (US)
LEDEBOER MARK (US)
HARRINGTON EDMUND (US)
GAO HUAI (US)

PCT/US2002/011570

January 03, 2003

April 10, 2002

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VERTEX PHARMA (US)
CAO JINGRONG (US)
GREEN JEREMY (US)
MOON YOUNG-CHOON (US)
WANG JIAN (US)
LEDEBOER MARK (US)
HARRINGTON EDMUND (US)
GAO HUAI (US)

A61K31/427; A61K31/506; A61L33/00; A61P1/00; A61P1/04; C12N15/09; A61P1/16; A61P1/18; A61P3/10; A61P3/14; A61P5/14; A61P7/04; A61P7/06; A61P9/00; A61P9/04; A61P9/10; A61P11/02; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P19/08; A61P19/10; A61P21/04; A61P25/00; A61P25/02; A61P25/14; A61P25/16; A61P25/28; A61P29/00; A61P31/00; A61P35/00; A61P35/02; A61P35/04; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D409/04; C07D409/14; C07D417/04; C07D417/14; C12N9/99; (IPC1-7): C07D409/00; C07D409/14; C07D417/14; A61K31/506; A61P35/00

WO2001012621A1

2001-02-22

US6114333A	2000-09-05
US5932576A	1999-08-03

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