INHIBITORS OF CATHEPSIN S

Title:

INHIBITORS OF CATHEPSIN S

Document Type and Number:

WIPO Patent Application WO2004112709

Kind Code:

A3

Abstract:

The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.

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Inventors:

LIU HONG (US)
TULLY DAVID (US)
ALPER PHILLIP (US)
EPPLE ROBERT (US)
CHATTERJEE ARNAB (US)
ROBERTS MICHAEL (US)

Application Number:

PCT/US2004/019194

Publication Date:

April 07, 2005

Filing Date:

June 14, 2004

Export Citation:

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Assignee:

IRM LLC (US)
LIU HONG (US)
TULLY DAVID (US)
ALPER PHILLIP (US)
EPPLE ROBERT (US)
CHATTERJEE ARNAB (US)
ROBERTS MICHAEL (US)

International Classes:

A61K31/421; A61K31/422; A61K31/423; A61K31/426; A61K31/427; A61K31/428; A61K31/47; A61K31/495; A61K31/4965; A61K31/537; A61K31/54; C07D277/82; C07D401/12; C07D403/12; C07D413/12; C07D417/12; A61K; (IPC1-7): A61K31/423; A61K31/427; A61K31/422; A61K31/428; A61K31/47; A61K31/4965; C07D413/12; C07D417/12; C07D401/12; C07D403/12; C07D277/82

Domestic Patent References:

WO2002070517A2

2002-09-12

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