INHIBITORS OF CATHEPSIN S

Title:

INHIBITORS OF CATHEPSIN S

Document Type and Number:

WIPO Patent Application WO2005034848

Kind Code:

A3

Abstract:

The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.

Inventors:

LIU HONG (US)
CHATTERJEE ARNAB (US)
TULLY DAVID C (US)
ALPER PHILLIP B (US)
BURSULAYA BADRY (US)
GUO JIANHUA (US)
WOODMANSEE DAVID (US)
MUTNICK DANIEL (US)
KARANEWSKY DONALD S (US)
HE YUN (US)

Application Number:

PCT/US2004/026986

Publication Date:

October 27, 2005

Filing Date:

August 19, 2004

Export Citation:

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Assignee:

IRM LLC (US)
LIU HONG (US)
CHATTERJEE ARNAB (US)
TULLY DAVID C (US)
ALPER PHILLIP B (US)
BURSULAYA BADRY (US)
GUO JIANHUA (US)
WOODMANSEE DAVID (US)
MUTNICK DANIEL (US)
KARANEWSKY DONALD S (US)
HE YUN (US)

International Classes:

A61K31/397; A61K31/401; A61K31/404; A61K31/423; A61K31/445; A61K31/454; A61K31/495; A61K31/537; A61K31/5375; A61K31/54; C07D209/04; C07D209/08; C07D261/14; C07D265/30; C07D295/13; C07D295/18; C07D295/20; C07D411/12; C07D413/12; C07D417/12; A61K; (IPC1-7): C07D209/04; C07D265/30; C07D295/13; C07D411/12; C07D413/12; C07D417/12; A61K31/404; A61K31/423; A61K31/454; A61K31/5375

Domestic Patent References:

WO2001081613A2

2001-11-01

Foreign References:

JP2004256525A	2004-09-16
US6313117B1	2001-11-06
US6504014B1	2003-01-07

Other References: