Title:
INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7)
Document Type and Number:
WIPO Patent Application WO/2015/154039
Kind Code:
A3
Abstract:
The present invention provides novel compounds of Formula (I) and Formula (II) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.
More Like This:
Inventors:
SPROTT KEVIN (US)
MARINEAU JASON J (US)
SCHMIDT DARBY (US)
BRADLEY MICHAEL (US)
CIBLAT STEPHANE (CA)
SIDDIQUI M ARSHAD (US)
KABRO ANZHELIKA (CA)
LEBLANC MELISSA (CA)
LEGER SERGE (CA)
ROY STEPHANIE (CA)
WINTER DANA K (CA)
MILLER TOM (US)
RIPKA AMY (US)
LI DANSU (US)
MARINEAU JASON J (US)
SCHMIDT DARBY (US)
BRADLEY MICHAEL (US)
CIBLAT STEPHANE (CA)
SIDDIQUI M ARSHAD (US)
KABRO ANZHELIKA (CA)
LEBLANC MELISSA (CA)
LEGER SERGE (CA)
ROY STEPHANIE (CA)
WINTER DANA K (CA)
MILLER TOM (US)
RIPKA AMY (US)
LI DANSU (US)
Application Number:
PCT/US2015/024358
Publication Date:
December 03, 2015
Filing Date:
April 03, 2015
Export Citation:
Assignee:
SYROS PHARMACEUTICALS INC (US)
International Classes:
A61K31/506; C07D401/14; A61P29/00; A61P31/00; A61P37/00; C07D403/04; C07D403/14; C07D405/04; C07D409/04; C07D411/14; C07D413/14; C07D417/04; C07D417/14; C07D471/04; C07D487/04; C07D487/10; C07D498/10
Domestic Patent References:
| WO2005116025A2 | 2005-12-08 | |||
| WO2011034907A2 | 2011-03-24 | |||
| WO2013074986A1 | 2013-05-23 | |||
| WO2014063068A1 | 2014-04-24 |
Foreign References:
| US20110034470A1 | 2011-02-10 |
Other References:
RICHARD A WARD ET AL: "Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR)", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 56, no. 17, 12 September 2013 (2013-09-12), pages 7025 - 7048, XP002734712, ISSN: 0022-2623, [retrieved on 20130809], DOI: 10.1021/JM400822Z
DATABASE PubChem Compound [online] NCBI; 16 September 2014 (2014-09-16), XP002740602, Database accession no. CID 77485161
DATABASE PubChem Compound [online] NCBI; 16 September 2014 (2014-09-16), XP002740602, Database accession no. CID 77485161
Attorney, Agent or Firm:
MCCARTY, Catherine, M. (Riverfront Office ParkOne Main Street, Suite 100, Cambridge MA, US)
Download PDF:
Previous Patent: INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7)
Next Patent: DOSIMETRY FOR RADIOTHERAPY TREATMENT VERIFICATION
Next Patent: DOSIMETRY FOR RADIOTHERAPY TREATMENT VERIFICATION