INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7)

WIPO Patent Application WO/2018/013867

A8

The present invention provides novel compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.

MARINEAU JASON (US)
ZAHLER ROBERT (US)
CIBLAT STEPHANE (CA)
WINTER DANA (CA)
KABRO ANZHELIKA (CA)
ROY STEPHANIE (CA)
SCHMIDT DARBY (US)
CHUAQUI CLAUDIO (US)
MALOJCIC GORAN (US)
PIRAS HENRI (CA)
WHITMORE KENNETH (CA)
LUND KATE-IYN (CA)
SINKO BILL (US)
SPROTT KEVIN (US)

PCT/US2017/042017

November 15, 2018

July 13, 2017

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MARINEAU JASON J (US)
ZAHLER ROBERT (US)
CIBLAT STEPHANE (CA)
WINTER DANA K (CA)
KABRO ANZHELIKA (CA)
ROY STEPHANIE (CA)
SCHMIDT DARBY (US)
CHUAQUI CLAUDIO (US)
MALOJCIC GORAN (US)
PIRAS HENRI (CA)
WHITMORE KENNETH MATTHEW (CA)
LUND KATE IYN (CA)
SINKO BILL (US)
SPROTT KEVIN (US)

C07D401/14; A61K31/506; A61P35/00

LARKIN, Angelyn et al. (US)

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