Title:
INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2
Document Type and Number:
WIPO Patent Application WO2006128142
Kind Code:
A8
Abstract:
This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A2 enzymes (cPLA2), more particularly including inhibitors of cytosolic phospholipase A2 alpha enzymes (cPLA2a). In some embodiments, the inhibitors have the Formula (I): wherein the constituent variables are as defined herein.
Inventors:
MCKEW JOHN C (US)
LEE KATHERINE L (US)
CHEN LIHREN (US)
VARGAS RICHARD (US)
CLARK JAMES D (US)
WILLIAMS CARA (US)
CLERIN VALERIE (US)
MARUSIC SUZANA (US)
PONG KEVIN (US)
LEE KATHERINE L (US)
CHEN LIHREN (US)
VARGAS RICHARD (US)
CLARK JAMES D (US)
WILLIAMS CARA (US)
CLERIN VALERIE (US)
MARUSIC SUZANA (US)
PONG KEVIN (US)
Application Number:
PCT/US2006/020847
Publication Date:
December 27, 2007
Filing Date:
May 26, 2006
Export Citation:
Assignee:
WYETH CORP (US)
MCKEW JOHN C (US)
LEE KATHERINE L (US)
CHEN LIHREN (US)
VARGAS RICHARD (US)
CLARK JAMES D (US)
WILLIAMS CARA (US)
CLERIN VALERIE (US)
MARUSIC SUZANA (US)
PONG KEVIN (US)
MCKEW JOHN C (US)
LEE KATHERINE L (US)
CHEN LIHREN (US)
VARGAS RICHARD (US)
CLARK JAMES D (US)
WILLIAMS CARA (US)
CLERIN VALERIE (US)
MARUSIC SUZANA (US)
PONG KEVIN (US)
International Classes:
C07D209/14; A61K31/404; A61P11/00; A61P19/00; A61P25/00
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