Title:
INHIBITORS OF FACTOR XA
Document Type and Number:
WIPO Patent Application WO2001019798
Kind Code:
A3
Abstract:
Compounds of formula A Q D E G J X in which D is a direct link, a substituted or unsubsituted phenyl or naphtyl gourp or a heterocyclic ring system; G is substituted or unsubstituted phenyl or a heterocyclic ring system; X is a substituted or unsubstituted phenyl or naphtyl group or a heterocyclic ring system; and the other variables are as defined in the claims, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed, The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Inventors:
ZHU BING-YAN
JIA ZHAOZHONG JON
HUANG WENRONG
SONG YONGHONG
KANTER JAMES
SCARBOROUGH ROBERT M
JIA ZHAOZHONG JON
HUANG WENRONG
SONG YONGHONG
KANTER JAMES
SCARBOROUGH ROBERT M
Application Number:
PCT/US2000/025195
Publication Date:
October 25, 2001
Filing Date:
September 15, 2000
Export Citation:
Assignee:
COR THERAPEUTICS INC (US)
International Classes:
A61K31/33; A61K31/415; A61K31/4155; A61K31/4178; A61K31/426; A61K31/427; A61K31/428; C07D231/14; A61K31/4439; A61K31/454; A61K31/4545; A61K31/4725; A61K31/496; A61K31/506; A61K31/5377; A61K31/541; A61K31/55; A61K31/551; A61P7/02; A61P7/04; A61P43/00; C07C311/16; C07C311/46; C07C317/40; C07C317/44; C07D213/75; C07D213/81; C07D213/82; C07D217/22; C07D277/20; C07D277/56; C07D333/38; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/04; C07D403/06; C07D403/10; C07D403/12; C07D403/14; C07D405/12; C07D409/12; C07D409/14; C07D417/04; C07D417/12; C07D417/14; C07D471/04; C07D487/04; C07D521/00; (IPC1-7): C07D231/14; C07D277/56; C07D401/12; C07D403/12; C07D417/04; A61K31/33; A61P7/04
Domestic Patent References:
| WO1998028269A1 | 1998-07-02 | |||
| WO1998028282A2 | 1998-07-02 | |||
| WO1998057934A1 | 1998-12-23 |
Other References:
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"Dictionary of Organic Compounds, 5th Ed., Vol. 5", 1982, CHAPMAN AND HALL, NEW YORK, US, XP002161122, 157909
Q.-Y. CHEN, ET AL.: "Photo-induced electron-transfer reaction of aryl perfluoroalkanesulphonates with anilines", JOURNAL OF FLUORINE CHEMISTRY, vol. 66, no. 1, January 1994 (1994-01-01), Elsevier Science Publishers, Amsterdam, NL, pages 59 - 62, XP002161119, ISSN: 0022-1139
T. KEUMI, ET AL.: "2-(Trifluoromethylsulphonyloxy)pyridine as a reagent for the ketone synthesis from carboxylic acids and aromatic hydrocarbons", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 61, no. 2, February 1988 (1988-02-01), Japan Publications Trading Co., Tokyo JP, pages 455 - 459, XP002161120, ISSN: 0009-2673
H.J SPIE, ET AL.: "An improved synthesis of aryl sulphones", SYNTHESIS, no. 3, March 1984 (1984-03-01), Georg Thieme Verlag, Stuttgart, DE, pages 283 - 284, XP002161121, ISSN: 0039-7881
"Dictionary of Organic Compounds, 5th Ed., Vol. 5", 1982, CHAPMAN AND HALL, NEW YORK, US, XP002161122, 157909
Q.-Y. CHEN, ET AL.: "Photo-induced electron-transfer reaction of aryl perfluoroalkanesulphonates with anilines", JOURNAL OF FLUORINE CHEMISTRY, vol. 66, no. 1, January 1994 (1994-01-01), Elsevier Science Publishers, Amsterdam, NL, pages 59 - 62, XP002161119, ISSN: 0022-1139
T. KEUMI, ET AL.: "2-(Trifluoromethylsulphonyloxy)pyridine as a reagent for the ketone synthesis from carboxylic acids and aromatic hydrocarbons", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 61, no. 2, February 1988 (1988-02-01), Japan Publications Trading Co., Tokyo JP, pages 455 - 459, XP002161120, ISSN: 0009-2673
H.J SPIE, ET AL.: "An improved synthesis of aryl sulphones", SYNTHESIS, no. 3, March 1984 (1984-03-01), Georg Thieme Verlag, Stuttgart, DE, pages 283 - 284, XP002161121, ISSN: 0039-7881
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