Title:
INHIBITORS OF GLYCOSIDASES AND GLYCOSYLTRANSFERASES
Document Type and Number:
WIPO Patent Application WO2000029418
Kind Code:
A3
Abstract:
Inhibitors of glycosidases and glycosyltransferases, methods for their preparation and their identification are described.
Inventors:
WONG CHI-HUEY
Application Number:
PCT/EP1999/008727
Publication Date:
August 03, 2000
Filing Date:
November 12, 1999
Export Citation:
Assignee:
NOVARTIS AG (CH)
NOVARTIS ERFIND VERWALT GMBH (AT)
SCRIPPS RESEARCH INST (US)
NOVARTIS ERFIND VERWALT GMBH (AT)
SCRIPPS RESEARCH INST (US)
International Classes:
C07F9/38; C07H3/02; C07H9/04; C07H15/12; C07H19/06; (IPC1-7): C07H15/12; A61K31/66; A61K31/70; C07F9/38; C07H3/02; C07H9/04; C07H19/06
Other References:
QIAO L ET AL: "Synergistic Inhibition of Human.alpha.-1,3-Fucosyltransferase V", J. AM. CHEM. SOC. (JACSAT,00027863);1996; VOL.118 (33); PP.7653-7662, Scripps Research Institute;Department of Chemistry; La Jolla; 92037; CA; USA (US), XP002127086
WISCHNAT R ET AL: "Chemoenzymic synthesis of iminocyclitol derivatives: a useful library strategy for the development of selective fucosyltransfer enzymes inhibitors", BIOORG. MED. CHEM. LETT. (BMCLE8,0960894X);1998; VOL.8 (23); PP.3353-3358, The Scripps Research Institute;Department of Chemistry and the Skaggs Institute for Chemical Biology; La Jolla; 92037; CA; USA (US), XP004143757
WISCHNAT R ET AL: "Synthesis of a New Class of N-Linked Lewis and LacNAc Analogs as Potential Inhibitors of Human Fucosyltransferases: A General Method for the Incorporation of an Iminocyclitol as a Transition-State Mimetic of the Donor Sugar to the Acceptor", J. ORG. CHEM. (JOCEAH,00223263);1998; VOL.63 (23); PP.8361-8365, The Scripps Research Institute;Department of Chemistry; La Jolla; 92037; CA; USA (US), XP002127087
WISCHNAT R ET AL: "Chemoenzymic synthesis of iminocyclitol derivatives: a useful library strategy for the development of selective fucosyltransfer enzymes inhibitors", BIOORG. MED. CHEM. LETT. (BMCLE8,0960894X);1998; VOL.8 (23); PP.3353-3358, The Scripps Research Institute;Department of Chemistry and the Skaggs Institute for Chemical Biology; La Jolla; 92037; CA; USA (US), XP004143757
WISCHNAT R ET AL: "Synthesis of a New Class of N-Linked Lewis and LacNAc Analogs as Potential Inhibitors of Human Fucosyltransferases: A General Method for the Incorporation of an Iminocyclitol as a Transition-State Mimetic of the Donor Sugar to the Acceptor", J. ORG. CHEM. (JOCEAH,00223263);1998; VOL.63 (23); PP.8361-8365, The Scripps Research Institute;Department of Chemistry; La Jolla; 92037; CA; USA (US), XP002127087
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