INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME

Title:

INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME

Document Type and Number:

WIPO Patent Application WO2004074270

Kind Code:

B1

Abstract:

The invention relates to compounds of the formula (I) and to pharmaceutically acceptable salts, solvates, prodrugs and metabolites thereof, wherein W, Z, R<1> and R<2>, are as defined herein. The invention also relates to methods of treating Hepatitis C virus in mammals by administering the compounds of formula (I), and to pharmaceutical compositions for treating such disorders, which contain the compounds of formula (I). The invention also relates to methods of preparing the compounds of formula (I).

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Inventors:

BORCHARDT ALLEN JOHN (US)
GONZALEZ JAVIER (US)
LI HUI (US)
LINTON MARIA ANGELICA (US)
TATLOCK JOHN HOWARD (US)

Application Number:

PCT/IB2004/000493

Publication Date:

March 17, 2005

Filing Date:

February 09, 2004

Export Citation:

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Assignee:

PFIZER (US)
BORCHARDT ALLEN JOHN (US)
GONZALEZ JAVIER (US)
LI HUI (US)
LINTON MARIA ANGELICA (US)
TATLOCK JOHN HOWARD (US)

International Classes:

A61K31/4025; A61K31/452; A61K31/496; A61K31/519; A61K31/5377; A61K31/541; A61P31/14; C07D263/58; C07D285/06; C07D309/32; C07D405/06; C07D405/10; C07D405/12; C07D405/14; C07D407/06; C07D407/10; C07D407/12; C07D409/06; C07D409/10; C07D413/02; C07D413/06; C07D413/10; C07D413/12; C07D413/14; C07D417/02; C07D417/06; C07D417/10; C07D417/12; C07D471/04; C07D473/30; C07D473/36; C07D487/04; C07D495/04; C07D513/04; (IPC1-7): C07D309/32; C07D405/06; C07D409/10; C07D413/10; C07D407/10; C07D413/12; C07D407/06; C07D405/12; C07D407/12; C07D417/10; C07D409/06; C07D471/04; C07D487/04; C07D285/06; C07D405/10; C07D413/06; C07D417/06; C07D495/04; C07D513/04; C07D405/14; C07D413/14; C07D417/12; C07D473/36; C07D473/30; A61K31/351; A61P31/14

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