Title:
INHIBITORS OF HIV REVERSE TRANSCRIPTASE
Document Type and Number:
WIPO Patent Application WO1999064048
Kind Code:
A9
Abstract:
Disclosed are multibinding compounds which inhibit the enzyme HIV reverse transcriptase, an enzyme which catalyzes the conversion of viral RNA to single stranded DNA. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each multibinding compound comprises at least one nucleoside reverse transcriptase inhibitor and at least one non-nucleoside reverse transcriptase inhibitor. The multibinding compounds of this invention are useful to inhibit HIV reverse transcriptase in vivo, and accordingly to inhibit HIV replication in vivo.
Inventors:
MAMMEN MATHAI (US)
OARE DAVID (US)
GRIFFIN JOHN H (US)
AGGEN JAMES (US)
OARE DAVID (US)
GRIFFIN JOHN H (US)
AGGEN JAMES (US)
Application Number:
PCT/US1999/012774
Publication Date:
July 20, 2000
Filing Date:
June 08, 1999
Export Citation:
Assignee:
ADVANCED MEDICINE INC (US)
MAMMEN MATHAI (US)
OARE DAVID (US)
GRIFFIN JOHN H (US)
AGGEN JAMES (US)
MAMMEN MATHAI (US)
OARE DAVID (US)
GRIFFIN JOHN H (US)
AGGEN JAMES (US)
International Classes:
C07D499/44; A01N57/34; A61K31/00; A61K31/357; A61K31/397; A61K31/407; A61K31/421; A61K31/424; A61K31/431; A61K31/439; A61K31/444; A61K31/4545; A61K31/496; A61K31/522; A61K31/536; A61K31/5377; A61K31/546; A61K31/551; A61K31/65; A61K31/7028; A61K31/7034; A61K31/7036; A61K31/7042; A61K31/7048; A61K31/7052; A61K31/7056; A61K31/7064; A61K31/7068; A61K31/7072; A61K38/00; A61K39/00; A61K39/395; A61K39/44; A61K47/48; A61K51/00; A61P31/04; A61P31/18; A61P43/00; C07C233/36; C07C233/78; C07C237/24; C07C237/26; C07C271/20; C07C275/42; C07C321/04; C07C323/12; C07C335/08; C07C335/32; C07D207/333; C07D211/58; C07D215/56; C07D233/90; C07D235/30; C07D263/28; C07D265/18; C07D401/06; C07D401/12; C07D401/14; C07D405/04; C07D413/14; C07D453/02; C07D471/04; C07D471/14; C07D473/00; C07D473/34; C07D475/04; C07D475/08; C07D477/00; C07D487/04; C07D487/06; C07D493/04; C07D493/06; C07D495/04; C07D498/04; C07D498/18; C07D501/20; C07D519/00; C07H15/236; C07H15/238; C07H15/26; C07H17/08; C07H19/06; C07H19/20; C07K2/00; C07K4/00; C12N9/99; C12P19/38; C12Q1/26; C12Q1/44; C12Q1/48; C12Q1/533; C40B30/04; C40B40/04; G01N33/15; G01N33/50; G01N33/53; G01N33/543; G01N33/566; G01N33/573; G01N33/68; G01N33/92; G01N37/00; C07B61/00; C07D207/32; (IPC1-7): A61K38/00; A61K39/00; A61K39/44; A61K39/395; A61K51/00; C07K2/00; C07K4/00; G01N33/53; G01N33/543; G01N33/566; A01N57/34; C12P19/38
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