Title:
INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY
Document Type and Number:
WIPO Patent Application WO/2019/118785
Kind Code:
A3
Abstract:
The present disclosure relates generally to therapeutic agents that may be useful inhibitors of Integrated Stress Response (ISR) pathway.
Inventors:
BERNALES SEBASTIAN (US)
CHAKRAVARTY SARVAJIT (US)
PUJALA BRAHMAM (US)
PANPATIL DAYANAND (US)
BHATT BHAWANA (US)
DELGADO OYARZO LUZ MARINA (CL)
NÚÑEZ VASQUEZ GONZALO ESTEBAN (CL)
URETA DÍAZ GONZALO ANDRÉS (CL)
CHAKRAVARTY SARVAJIT (US)
PUJALA BRAHMAM (US)
PANPATIL DAYANAND (US)
BHATT BHAWANA (US)
DELGADO OYARZO LUZ MARINA (CL)
NÚÑEZ VASQUEZ GONZALO ESTEBAN (CL)
URETA DÍAZ GONZALO ANDRÉS (CL)
Application Number:
PCT/US2018/065555
Publication Date:
August 01, 2019
Filing Date:
December 13, 2018
Export Citation:
Assignee:
PRAXIS BIOTECH LLC (US)
International Classes:
A61K31/538; A61P25/00; C07D265/36
Foreign References:
| US20170342020A1 | 2017-11-30 | |||
| US20050197350A1 | 2005-09-08 |
Other References:
HEARN ET AL.: "Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response", CHEMMEDCHEM, vol. 11, 2016, pages 870 - 880, XP055383675
DATABASE PUBCHEM Compound 29 November 2013 (2013-11-29), "N-[2-[[2-(2,4-Dichlorophenoxy)acetyl]amino]ethyl]quinoline-2-carboxamide | C20H17Cl2N3O3", XP055632740, retrieved from NCBI Database accession no. 71946601
DATABASE Pubchem Compound 9 July 2005 (2005-07-09), "Isrib | C22H24Cl2N2O4", XP055632742, retrieved from NCBI Database accession no. 1011240
DATABASE Pubchem Compound 25 January 2012 (2012-01-25), "N-[2-(4-Chlorophenoxy)ethyl]-1-(3-phenoxypropanoyl)piperidine-4-carboxamide | C23H27ClN2O4", XP055632746, retrieved from NCBI Database accession no. 55856026
DATABASE PUBCHEM Compound 29 November 2013 (2013-11-29), "N-[2-[[2-(2,4-Dichlorophenoxy)acetyl]amino]ethyl]quinoline-2-carboxamide | C20H17Cl2N3O3", XP055632740, retrieved from NCBI Database accession no. 71946601
DATABASE Pubchem Compound 9 July 2005 (2005-07-09), "Isrib | C22H24Cl2N2O4", XP055632742, retrieved from NCBI Database accession no. 1011240
DATABASE Pubchem Compound 25 January 2012 (2012-01-25), "N-[2-(4-Chlorophenoxy)ethyl]-1-(3-phenoxypropanoyl)piperidine-4-carboxamide | C23H27ClN2O4", XP055632746, retrieved from NCBI Database accession no. 55856026
Attorney, Agent or Firm:
REANEY, Shannon (US)
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