Title:
INHIBITORS OF THE INTERACTION OF THE SIGMA-1 RECEPTOR WITH hERG FOR USE IN THE TREATMENT OF CANCER
Document Type and Number:
WIPO Patent Application WO/2012/104550
Kind Code:
A3
Abstract:
The present invention relates to the use of the Sigma-1 receptor (Sig1R) in the context of the post-transcriptional regulation of ion channel membrane expression. The present invention can be used in the field of the treatment of diseases involving ion channels. They are, for example, nervous system diseases, neurodegenerative diseases, heart diseases, and cancer.
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Inventors:
SORIANI OLIVIER (FR)
BORGESE MAURO FRANCK (FR)
MARTIAL SONIA (FR)
BORGESE MAURO FRANCK (FR)
MARTIAL SONIA (FR)
Application Number:
PCT/FR2012/050213
Publication Date:
October 26, 2012
Filing Date:
January 31, 2012
Export Citation:
Assignee:
CENTRE NAT RECH SCIENT (FR)
UNIV NICE SOPHIA ANTIPOLIS (FR)
SORIANI OLIVIER (FR)
BORGESE MAURO FRANCK (FR)
MARTIAL SONIA (FR)
UNIV NICE SOPHIA ANTIPOLIS (FR)
SORIANI OLIVIER (FR)
BORGESE MAURO FRANCK (FR)
MARTIAL SONIA (FR)
International Classes:
A61K31/00; A61K38/17; A61P9/00; A61P25/00; A61P35/00
Domestic Patent References:
| WO2010101649A2 | 2010-09-10 | |||
| WO2010015040A1 | 2010-02-11 | |||
| WO2006039806A1 | 2006-04-20 |
Other References:
RUSCHER KARSTEN ET AL: "The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke", BRAIN, OXFORD UNIVERSITY PRESS, OXFORD, GB, vol. 134, no. Part 3, 28 January 2011 (2011-01-28), pages 732 - 746, XP009151923, ISSN: 0006-8950
S. PILLOZZI ET AL: "VEGFR-1 (FLT-1), 1 integrin, and hERG K+ channel for a macromolecular signaling complex in acute myeloid leukemia: role in cell migration and clinical outcome", BLOOD, vol. 110, no. 4, 9 April 2007 (2007-04-09), pages 1238 - 1250, XP055006470, ISSN: 0006-4971, DOI: 10.1182/blood-2006-02-003772
A. RENAUDO ET AL: "Cancer Cell Cycle Modulated by a Functional Coupling between Sigma-1 Receptors and Cl- Channels", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, no. 4, 1 January 2006 (2006-01-01), pages 2259 - 2267, XP055006487, ISSN: 0021-9258, DOI: 10.1074/jbc.M607915200
A. CHERUBINI: "Human ether-a-go-go-related Gene 1 Channels Are Physically Linked to 1 Integrins and Modulate Adhesion-dependent Signaling", MOLECULAR BIOLOGY OF THE CELL, vol. 16, no. 6, 1 January 2005 (2005-01-01), pages 2972 - 2983, XP055006492, ISSN: 1059-1524, DOI: 10.1091/mbc.E04-10-0940
A. RENAUDO: "Inhibition of Tumor Cell Proliferation by Ligands Is Associated with K+ Channel Inhibition and p27kip1 Accumulation", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 311, no. 3, 1 January 2004 (2004-01-01), pages 1105 - 1114, XP055006496, ISSN: 0022-3565, DOI: 10.1124/jpet.104.072413
MAURICE T ET AL: "The pharmacology of sigma-1 receptors", PHARMACOLOGY AND THERAPEUTICS, ELSEVIER, GB, vol. 124, no. 2, 1 November 2009 (2009-11-01), pages 195 - 206, XP026626456, ISSN: 0163-7258, [retrieved on 20090718], DOI: 10.1016/J.PHARMTHERA.2009.07.001
D. CROTTES ET AL: "Sig1R Protein Regulates hERG Channel Expression through a Post-translational Mechanism in Leukemic Cells", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286, no. 32, 16 June 2011 (2011-06-16), pages 27947 - 27958, XP055006465, ISSN: 0021-9258, DOI: 10.1074/jbc.M111.226738
PILLOZZI S ET AL: "Chemotherapy resistance in acute lymphoblastic leukemia requires hERG1 channels and is overcome by hERG1 blockers", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 117, no. 3, 1 January 2011 (2011-01-01), pages 902 - 914, XP008134468, ISSN: 0006-4971, [retrieved on 20101103], DOI: 10.1162/BLOOD-2010-02-262591
MORI T ET AL: "Compromising sigma-1 receptors at the ER renders cytotoxicity to physiologically relevant concentrations of dopamine in a Bcl-2-dependent mechanism: Potential relevance to Parkinson's disease", SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER, vol. 40, 663.17, 16 November 2010 (2010-11-16), & 40TH ANNUAL MEETING OF THE SOCIETY-FOR-NEUROSCIENCE; SAN DIEGO, CA, USA; NOVEMBER 13 -17, 2010, pages 1 - 3, XP009160948
WANG L ET AL: "Silencing of sigma-1 receptor induces cell death in human lens cells", EXPERIMENTAL CELL RESEARCH, ACADEMIC PRESS, US, vol. 312, no. 8, 1 May 2006 (2006-05-01), pages 1439 - 1446, XP024945035, ISSN: 0014-4827, [retrieved on 20060501], DOI: 10.1016/J.YEXCR.2006.01.004
S. PILLOZZI ET AL: "VEGFR-1 (FLT-1), 1 integrin, and hERG K+ channel for a macromolecular signaling complex in acute myeloid leukemia: role in cell migration and clinical outcome", BLOOD, vol. 110, no. 4, 9 April 2007 (2007-04-09), pages 1238 - 1250, XP055006470, ISSN: 0006-4971, DOI: 10.1182/blood-2006-02-003772
A. RENAUDO ET AL: "Cancer Cell Cycle Modulated by a Functional Coupling between Sigma-1 Receptors and Cl- Channels", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, no. 4, 1 January 2006 (2006-01-01), pages 2259 - 2267, XP055006487, ISSN: 0021-9258, DOI: 10.1074/jbc.M607915200
A. CHERUBINI: "Human ether-a-go-go-related Gene 1 Channels Are Physically Linked to 1 Integrins and Modulate Adhesion-dependent Signaling", MOLECULAR BIOLOGY OF THE CELL, vol. 16, no. 6, 1 January 2005 (2005-01-01), pages 2972 - 2983, XP055006492, ISSN: 1059-1524, DOI: 10.1091/mbc.E04-10-0940
A. RENAUDO: "Inhibition of Tumor Cell Proliferation by Ligands Is Associated with K+ Channel Inhibition and p27kip1 Accumulation", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 311, no. 3, 1 January 2004 (2004-01-01), pages 1105 - 1114, XP055006496, ISSN: 0022-3565, DOI: 10.1124/jpet.104.072413
MAURICE T ET AL: "The pharmacology of sigma-1 receptors", PHARMACOLOGY AND THERAPEUTICS, ELSEVIER, GB, vol. 124, no. 2, 1 November 2009 (2009-11-01), pages 195 - 206, XP026626456, ISSN: 0163-7258, [retrieved on 20090718], DOI: 10.1016/J.PHARMTHERA.2009.07.001
D. CROTTES ET AL: "Sig1R Protein Regulates hERG Channel Expression through a Post-translational Mechanism in Leukemic Cells", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286, no. 32, 16 June 2011 (2011-06-16), pages 27947 - 27958, XP055006465, ISSN: 0021-9258, DOI: 10.1074/jbc.M111.226738
PILLOZZI S ET AL: "Chemotherapy resistance in acute lymphoblastic leukemia requires hERG1 channels and is overcome by hERG1 blockers", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 117, no. 3, 1 January 2011 (2011-01-01), pages 902 - 914, XP008134468, ISSN: 0006-4971, [retrieved on 20101103], DOI: 10.1162/BLOOD-2010-02-262591
MORI T ET AL: "Compromising sigma-1 receptors at the ER renders cytotoxicity to physiologically relevant concentrations of dopamine in a Bcl-2-dependent mechanism: Potential relevance to Parkinson's disease", SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER, vol. 40, 663.17, 16 November 2010 (2010-11-16), & 40TH ANNUAL MEETING OF THE SOCIETY-FOR-NEUROSCIENCE; SAN DIEGO, CA, USA; NOVEMBER 13 -17, 2010, pages 1 - 3, XP009160948
WANG L ET AL: "Silencing of sigma-1 receptor induces cell death in human lens cells", EXPERIMENTAL CELL RESEARCH, ACADEMIC PRESS, US, vol. 312, no. 8, 1 May 2006 (2006-05-01), pages 1439 - 1446, XP024945035, ISSN: 0014-4827, [retrieved on 20060501], DOI: 10.1016/J.YEXCR.2006.01.004
Attorney, Agent or Firm:
NOVAGRAAF TECHNOLOGIES (Levallois Perret Cedex, Levallois Perret Cedex, FR)
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