INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION

Title:

INHIBITORS OF KEAP1-NRF2 PROTEIN-PROTEIN INTERACTION

Document Type and Number:

WIPO Patent Application WO/2020/041169

Kind Code:

A3

Abstract:

Sultam compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with the KEAP1-Nrf2 interaction, such as inflammatory bowel disease, including Crohn's disease and ulcerative colitis.

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Inventors:

BARBAY J KENT (US)
CHAI WENYING (US)
HIRST GAVIN C (US)
KREUTTER KEVIN D (US)
KUMMER DAVID A (US)
MCCLURE KELLY J (US)
NISHIMURA RACHEL T (US)
SHIH AMY Y (US)
VENABLE JENNIFER D (US)
VENKATESAN HARIHARAN (US)
WEI JIANMEI (US)

Application Number:

PCT/US2019/047015

Publication Date:

April 02, 2020

Filing Date:

August 19, 2019

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Assignee:

JANSSEN PHARMACEUTICA NV (BE)
BARBAY J KENT (US)

International Classes:

C07D417/10; A61K31/554; C07D417/14; C07D419/10; C07D419/14; C07D471/04; C07D487/04; C07D513/04; C07D513/14; C07D515/04; C07D515/14; A61P3/00; A61P9/00; A61P11/00; A61P29/00

Domestic Patent References:

WO2015092713A1

2015-06-25

Other References:

DAVIES, T.G. ET AL.: "Monoacidic inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor erythroid 2-related factor 2 (KEAP1:NRF2) protein-protein interaction with high cell potency identified by fragment-based discovery", J. MED. CHEM., vol. 59, 2016, pages 3991 - 4006, XP055289126

Attorney, Agent or Firm:

SHIRTZ, Joseph F. et al. (US)

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