INHIBITORS OF PRENYL-PROTEIN TRANSFERASE

Title:

INHIBITORS OF PRENYL-PROTEIN TRANSFERASE

Document Type and Number:

WIPO Patent Application WO2000034239

Kind Code:

A3

Abstract:

The present invention is directed to compounds which inhibit prenyl-protein transferase and particularly, the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

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Inventors:

DESOLMS S JANE (US)
SHAW ANTHONY W (US)

Application Number:

PCT/US1999/029175

Publication Date:

September 08, 2000

Filing Date:

December 07, 1999

Export Citation:

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Assignee:

MERCK & CO INC (US)
DESOLMS S JANE (US)
SHAW ANTHONY W (US)

International Classes:

C07D498/18; (IPC1-7): C07D273/02; A61K31/55

Foreign References:

EP0675112A1

1995-10-04

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