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Title:
INHIBITORS OF RETROVIRAL REPLICATION
Document Type and Number:
WIPO Patent Application WO/2012/096934
Kind Code:
A3
Abstract:
Methods for preventing or treating retroviral infection, such as human immunodeficiency virus, in vivo utilize transcriptional inhibitory compounds. These include cortistatin A and analogs of the cortistatin family.

Inventors:
VALENTE, Susana (265 Cardinal Trail, Stuart, FL, 34997, US)
BARAN, Phil, S. (5160 Great Meadow Drive, San Diego, CA, 92130, US)
Application Number:
US2012/020741
Publication Date:
July 19, 2012
Filing Date:
January 10, 2012
Export Citation:
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Assignee:
THE SCRIPPS RESEARCH INSTITUTE (10550 North Torrey Pines Road, La Jolla, CA, 92037, US)
VALENTE, Susana (265 Cardinal Trail, Stuart, FL, 34997, US)
BARAN, Phil, S. (5160 Great Meadow Drive, San Diego, CA, 92130, US)
International Classes:
C07J71/00; C07D273/00; C07D319/00; C07D321/00; C07D401/00
Domestic Patent References:
WO2009137335A12009-11-12
WO2010024930A22010-03-04
Foreign References:
US6365787B12002-04-02
US20120071477A12012-03-22
Other References:
TOSCHI ET AL.: "HIV-1 Tat Regulates Endothelial Cell Cycle Progression via Activation of the Ras/ERK MAPK Signaling Pathway", MOLECULAR BIOLOGY OF THE CELL, vol. 17, no. 4, 25 January 2006 (2006-01-25), pages 1985 - 1994, XP055119584, Retrieved from the Internet [retrieved on 20120713]
See also references of EP 2663574A4
Attorney, Agent or Firm:
ZACHARIADES, Nicholas, A. (Duane Morris LLP, 2700 North Military TrailSuite 30, Boca Raton FL, 33431, US)
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