INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE

Title:

INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE

Document Type and Number:

WIPO Patent Application WO2005077969

Kind Code:

A3

Abstract:

The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection and to processes for preparing the compounds. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds.

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Inventors:

COTTRELL KEVIN M (US)
COURT JOHN J (US)
DEININGER DAVID D (US)
FARMER LUC J (US)
PITLIK JANOS (US)
PERNI ROBERT B (US)

Application Number:

PCT/US2005/003381

Publication Date:

December 01, 2005

Filing Date:

February 04, 2005

Export Citation:

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Assignee:

VERTEX PHARMA (US)
COTTRELL KEVIN M (US)
COURT JOHN J (US)
DEININGER DAVID D (US)
FARMER LUC J (US)
PITLIK JANOS (US)
PERNI ROBERT B (US)

International Classes:

A61K38/04; A61K38/05; C07K5/02; C07K5/04; C07K7/02; C07K14/18; A61K38/00; (IPC1-7): C07K7/02; C07K5/02; C07K14/18; A61K38/08; A61K38/07

Domestic Patent References:

WO2003091202A1	2003-11-06
WO2003006490A1	2003-01-23
WO2003087092A2	2003-10-23
WO2002018369A2	2002-03-07
WO1999017775A1	1999-04-15
WO2000016767A1	2000-03-30
WO2003062265A2	2003-07-31
WO2004072243A2	2004-08-26
WO2004093798A2	2004-11-04
WO2004113365A2	2004-12-29

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