Title:
INHIBITORY OLIGONUCLEOTIDES TARGETED TO MATRIX METALLOPROTEINASE-9
Document Type and Number:
WIPO Patent Application WO2004035759
Kind Code:
A3
Abstract:
Inhibitory oligonucleotides are disclosed which are targeted to six specific target regions found on nucleic acids encoding matrix-metalloprotein-9. These inhibitory oligonucleotides are generally of from about 8 to about 50 nucleotides in length. Presently preferred oligonucleotides are disclosed. The oligonucleotides of the invention may be incorporated into compositions such as pharmaceutical compositions, and may additionally be used in methods of inhibiting the expression of matrix metalloproteinase-9 in a cell or tissue.
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Inventors:
RUFFNER DUANE E
Application Number:
PCT/US2003/033141
Publication Date:
March 31, 2005
Filing Date:
October 17, 2003
Export Citation:
Assignee:
GENTA SALUS LLC (US)
International Classes:
C12N15/113; (IPC1-7): C12Q1/68; A01N43/04; A61K31/07; C07H21/04
Domestic Patent References:
| WO1999013886A1 | 1999-03-25 |
Other References:
JEN ET AL.: "Suppression of gene expression by targeted disruption of messanger RNA: available options and current strategies", STEM CELLS, vol. 18, 2000, pages 307 - 319
BRANCH A.: "A good antisense molecule is hard to find", TIBS, vol. 23, 1998, pages 45 - 50, XP004108000, DOI: doi:10.1016/S0968-0004(97)01155-9
BRANCH A.: "A good antisense molecule is hard to find", TIBS, vol. 23, 1998, pages 45 - 50, XP004108000, DOI: doi:10.1016/S0968-0004(97)01155-9
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