INJECTABLE COMPOSITION CONTAINING PRODRUG OF CASPASE INHIBITORS, AND PREPARATION METHOD THEREFOR

Title:

INJECTABLE COMPOSITION CONTAINING PRODRUG OF CASPASE INHIBITORS, AND PREPARATION METHOD THEREFOR

Document Type and Number:

WIPO Patent Application WO/2020/242234

Kind Code:

A1

Abstract:

The present invention relates to an injectable pharmaceutical composition containing a prodrug of caspase inhibitors, and a preparation method therefor. More specifically, the present invention relates to an injectable pharmaceutical composition, and a preparation method therefor, the composition comprising, as an active ingredient, (2S,3S)-2-(fluoromethyl)-3-((R)-5-isopropyl-3-(isoquinolin-1-yl)-4,5-dihydroisoxazole-5-carboxamido)-5-oxotetrahydrofuran-2-yl acetate, which is a prodrug of caspase inhibitors, or a pharmaceutically acceptable salt or isomer thereof, and comprising, as a biocompatible polymer, microspheres containing poly(lactide-co-glycolide).

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Inventors:

KIM SUNG WON (KR)
BAEK JAE UK (KR)
PARK HYUN SEO (KR)
JIN MYUNG WON (KR)
PARK JUNG GYU (KR)
KIM BOK TAE (KR)
CHOI SEI HYUN (KR)

Application Number:

PCT/KR2020/006953

Publication Date:

December 03, 2020

Filing Date:

May 29, 2020

Export Citation:

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Assignee:

LG CHEMICAL LTD (KR)

International Classes:

A61K9/16; A61K9/00; A61K9/19; A61K31/4725; A61K41/17; A61P19/02; A61P29/00

Domestic Patent References:

WO2006090997A1	2006-08-31
WO2010005765A1	2010-01-14
WO2007015931A2	2007-02-08

Foreign References:

KR20090116494A	2009-11-11
KR20140120496A	2014-10-14
EP3395364A1	2018-10-31
KR20040066726A	2004-07-27
KR20060013107A	2006-02-09
KR20080025123A	2008-03-19

Other References: