Title:
INJECTABLE LURASIDONE SUSPENSION AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/206447
Kind Code:
A1
Abstract:
The present disclosure relates to an injectable lurasidone suspension and a preparation method thereof, and in particular to an irregular form of a lurasidone solid and a pharmaceutical composition thereof. The present disclosure also relates to a preparation method for the solid and the pharmaceutical composition thereof, and an application thereof in the treatment of mental diseases. According to the present disclosure, the lurasidone solid prepared has controllable particle size and has Dv50 particle size of 6 μm to 110 μm. The good particle size stability can also be maintained in the pharmaceutical composition. The lurasidone suspension preparation obtained by the method is fast-acting, has a long sustained release period, and can effectively reduce the risk caused by poor patient compliance.
Inventors:
LI MING (CN)
LIANG XIANGYONG (CN)
SU ZHENGXING (CN)
LI DAN (CN)
KE DUO (CN)
YI CONG (CN)
WEI WEI (CN)
DENG GUIFU (CN)
PENG YA (CN)
ZHAO DONG (CN)
WANG JINGYI (CN)
LIANG XIANGYONG (CN)
SU ZHENGXING (CN)
LI DAN (CN)
KE DUO (CN)
YI CONG (CN)
WEI WEI (CN)
DENG GUIFU (CN)
PENG YA (CN)
ZHAO DONG (CN)
WANG JINGYI (CN)
Application Number:
PCT/CN2022/081937
Publication Date:
October 06, 2022
Filing Date:
March 21, 2022
Export Citation:
Assignee:
SICHUAN KELUN PHARM RES INST CO LTD (CN)
International Classes:
C07D417/12; A61K9/10; A61K31/496; A61K47/10; A61P25/00; A61P25/18; A61P25/24
Domestic Patent References:
| WO2014102834A2 | 2014-07-03 | |||
| WO2014064714A2 | 2014-05-01 | |||
| WO2017154021A1 | 2017-09-14 | |||
| WO2019213286A1 | 2019-11-07 |
Foreign References:
| US20150018368A1 | 2015-01-15 | |||
| CN107759583A | 2018-03-06 | |||
| US20190336439A1 | 2019-11-07 | |||
| CN103249416A | 2013-08-14 | |||
| CN106916151A | 2017-07-04 | |||
| US20170246165A1 | 2017-08-31 | |||
| US20140243529A1 | 2014-08-28 | |||
| CN110734434A | 2020-01-31 | |||
| US20150361099A1 | 2015-12-17 | |||
| US20170349601A1 | 2017-12-07 | |||
| US20140256939A1 | 2014-09-11 | |||
| CN107936007A | 2018-04-20 | |||
| CN106146486A | 2016-11-23 | |||
| CN202110348916A | 2021-03-31 | |||
| CN109998991A | 2019-07-12 | |||
| CN103249416A | 2013-08-14 | |||
| CN103249416A | 2013-08-14 |
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
Download PDF: