Title:
INSECT AND TICK G-COUPLED RECEPTORS USEFUL AS TARGETS FOR INSECTICIDES AND COMPOUNDS AND REAGENTS IDENTIFIED USING THE SAME
Document Type and Number:
WIPO Patent Application WO/2013/067519
Kind Code:
A3
Abstract:
An approach to identify and evaluate potential insecticide targets using publicly available genome (DNA) sequence information for arthropod disease vector is provided. The utility of this approach is demonstrated by first determining the molecular and pharmacological properties of two different dopamine (neurotransmitter) receptors identified in the genome of the yellow fever- and dengue-transmitting mosquito, Aedes aegypti. Next, different chemistries were tested for their ability to interact with one of these dopamine receptors in a chemical compound screen, and "hit" compounds were identified. Finally, it is shown that some of these chemistries, are selective for the mosquito over the human dopamine receptor and that these chemistries caused significant mortality in mosquito larvae 24 hours after exposure.
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Inventors:
HILL CATHERINE A (US)
WATTS VAL J (US)
WATTS VAL J (US)
Application Number:
PCT/US2012/063585
Publication Date:
July 11, 2013
Filing Date:
November 05, 2012
Export Citation:
Assignee:
PURDUE RESEARCH FOUNDATION (US)
International Classes:
A01N43/60; A01N43/40; A01P7/00; C12N15/11
Domestic Patent References:
| WO2010117740A2 | 2010-10-14 | |||
| WO2011036536A2 | 2011-03-31 |
Foreign References:
| US20100144888A1 | 2010-06-10 | |||
| EP2067787A1 | 2009-06-10 | |||
| US20080058430A1 | 2008-03-06 |
Other References:
OSBORNE, RICHARD H.: "Insect neurotransmission: neurotransmitters and their receptors.", PHARMACOLOGY AND THERAPEUTICS., vol. 69, no. 2, 31 December 1996 (1996-12-31), pages 117 - 142, XP001011507
MEYER, JASON M. ET AL.: "Molecular and pharmacological characterization of t wo D(l)-like dopamine receptors in the Lyme disease vector, Ixodes scapulari s.", INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY., vol. 41, no. 8, 30 March 2011 (2011-03-30), pages 563 - 571, XP028233246
MEYER, JASON M. ET AL.: "Molecular and pharmacological characterization of t wo D(l)-like dopamine receptors in the Lyme disease vector, Ixodes scapulari s.", INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY., vol. 41, no. 8, 30 March 2011 (2011-03-30), pages 563 - 571, XP028233246
Attorney, Agent or Firm:
BICKLEY, Patrick, M. (300 North Meridian StreetSuite 270, Indianapolis IN, US)
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