Title:
INSTRUMENT FOR SELECTING AND DEPOSITING MULTICELLULAR ORGANISMS AND OTHER LARGE OBJECTS
Document Type and Number:
WIPO Patent Application WO2000011449
Kind Code:
A9
Abstract:
An instrument for analyzing and dispensing objects larger than about 70 mu m in diameter is based on a flow cytometer with a novel fluidic switch arrangement for diverting a portion of a sample stream in response to detector signals in a flow cell. The instrument is particularly adapted for dispensing multicellular test organisms like nematodes or large microspheres for use in screening large libraries of potential pharmaceutical agents. Hydrodynamic focussing is used to center and align the objects in the flow cell. The objects pass through a sensing zone where optical or other characteristics of the objects are detected. The detector signals are processed and used to operate a fluidic switch that is located downstream from the sensing zone. The fluid stream containing the detected objects emerges from the flow cell into air where a fluid stream controlled by the fluidic switch diverts portions of the stream containing no sample objects or sample objects not meeting predetermined characteristics. The undiverted sample stream deposits selected sample objects into a plurality of containers.
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Inventors:
HANSEN W PETER (US)
Application Number:
PCT/US1999/019035
Publication Date:
July 13, 2000
Filing Date:
August 20, 1999
Export Citation:
Assignee:
UNION BIOMETRICA INC (US)
International Classes:
C12M1/34; G01N33/483; C12Q1/06; G01N15/14; G01N15/00; (IPC1-7): G01N15/14
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