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Title:
INSULIN A-CHAIN DERIVED PEPTIDE FRAGMENT AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DIABETES OR DIABETIC WOUNDS, CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2018/147624
Kind Code:
A1
Abstract:
Provided in the present invention are an insulin A-chain derived peptide fragment and a pharmaceutical composition for preventing or treating diabetes or diabetic wounds, containing the same as an active ingredient. The peptide of the present invention induces endocytosis through insulin receptors, has activities of increasing glucose uptake of cells by translocating glucose transporters onto a cell membrane, and of increasing cell migration and proliferation. Therefore, the peptide of the present invention can be usefully applicable in the prevention or treatment of diabetes or diabetic wounds.

Inventors:
HAHN, Jang-Hee (104-1401, 11 Namchuncheonsae-gil,Chuncheon-si, Gangwon-do, 24375, KR)
KIM, Chang-Gyum (101-902, 7 Guksabong-gil,Chuncheon-si, Gangwon-do, 24446, KR)
Application Number:
KR2018/001620
Publication Date:
August 16, 2018
Filing Date:
February 07, 2018
Export Citation:
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Assignee:
KNU-INDUSTRY COOPERATION FOUNDATION (1 Gangwondaehak-gil, Chuncheon-si, Gangwon-do, 24341, KR)
SUPADELIXIR INC. (Medical School Building 1-410, 1 Gangwondaehak-gil,Chuncheon-si, Gangwon-do, 24341, KR)
International Classes:
C07K5/083; A61K38/06; A61K38/07; C07K5/103
Domestic Patent References:
WO2006019015A12006-02-23
Foreign References:
KR20160125988A2016-11-01
JP2014506579A2014-03-17
JP2003176237A2003-06-24
Other References:
ASSOIAN, R. K.: "Peptide intermediates in the cellular metabolism of insulin", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 257, no. 15, 10 August 1982 (1982-08-10), pages 9078 - 9085, XP055534604
Attorney, Agent or Firm:
OH, Kook-Jin (302 Dooeon Bldg, 24 Beobwon-ro 3-gil,Seocho-gu, Seoul, 06595, KR)
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