INSULIN A-CHAIN DERIVED PEPTIDE FRAGMENT AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DIABETES OR DIABETIC WOUNDS, CONTAINING SAME

WIPO Patent Application WO/2018/147624

A1

Provided in the present invention are an insulin A-chain derived peptide fragment and a pharmaceutical composition for preventing or treating diabetes or diabetic wounds, containing the same as an active ingredient. The peptide of the present invention induces endocytosis through insulin receptors, has activities of increasing glucose uptake of cells by translocating glucose transporters onto a cell membrane, and of increasing cell migration and proliferation. Therefore, the peptide of the present invention can be usefully applicable in the prevention or treatment of diabetes or diabetic wounds.

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HAHN JANG-HEE (KR)
KIM CHANG-GYUM (KR)

PCT/KR2018/001620

August 16, 2018

February 07, 2018

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KNU INDUSTRY COOPERATION FOUND (KR)
SUPADELIXIR INC (KR)

C07K5/083; A61K38/06; A61K38/07; C07K5/103

WO2006019015A1

2006-02-23

KR20160125988A	2016-11-01
JP2014506579A	2014-03-17
JP2003176237A	2003-06-24

ASSOIAN, R. K.: "Peptide intermediates in the cellular metabolism of insulin", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 257, no. 15, 10 August 1982 (1982-08-10), pages 9078 - 9085, XP055534604

OH, Kook-Jin (KR)

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