Title:
INSULIN-INDUCIBLE POLYPEPTIDE
Document Type and Number:
WIPO Patent Application WO/2005/056784
Kind Code:
A1
Abstract:
An insulin-inducible polypeptide which is a partial peptide of Bacillus subtilis natto kinase having a sequence corresponding to the 50 or more consecutive amino acids starting with the amino acid at the 20-position (from the N-terminus) toward the C-terminus in the amino acid sequence constituting the natto kinase, or an amino acid sequence derived from the above sequence by deletion or addition of a plural number of amino acids or substitution thereof by other amino acids; and an oral composition containing this polypeptide. The above polypeptide and composition exhibit a therapeutic effect on diabetes when orally administered.
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Inventors:
NAKATSUGAWA SHIGEKAZU (JP)
Application Number:
PCT/JP2004/019153
Publication Date:
June 23, 2005
Filing Date:
December 15, 2004
Export Citation:
Assignee:
JAPAN SCIENCE & TECH AGENCY (JP)
NAKATSUGAWA SHIGEKAZU (JP)
NAKATSUGAWA SHIGEKAZU (JP)
International Classes:
A23L1/305; A61P3/10; C12N9/12; C12N15/09; A61K38/00; (IPC1-7): C12N9/12; A23L1/305; A61K38/00; A61P3/10; C12N15/09
Foreign References:
| JP2002360220A | 2002-12-17 |
Other References:
HUTTON J. C. ET AL: "Insulin secretory granule biogenesis and the proinsulin-processing endopeptidases", DIABETOLOGIA, vol. 37, no. 2, 1994, pages S48 - S56, XP002985930
DATABASE GENBANK [online] "Bacillus subtilis var. natto serkinase-nattokinase gene, complete cds", XP002985931, accession no. AF368283
DATABASE GENBANK [online] "Bacillus subtilis var. natto serkinase-nattokinase gene, complete cds", XP002985931, accession no. AF368283
Attorney, Agent or Firm:
Nishizawa, Toshio (11-1 Minami-Aoyama 6-chom, Minato-ku Tokyo, JP)
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