Title:
INSULIN RESISTANCE REDUCER
Document Type and Number:
WIPO Patent Application WO/2008/012932
Kind Code:
A1
Abstract:
As one example of investigating effects of accumulation of chondroitin sulfate proteoglycan (CSPG), the invention relates to a versican siRNA containing a core site sequence of versican which is one of the chondroitin sulfate proteoglycans, an siRNA of C4ST1, C4ST2 or C4ST3 which is an enzyme transferring a sulfate group of acetylgalactosamine being a side chain of chondroitin sulfate proteoglycan, and an insulin resistance reducer suitable for gene therapy or prevention for a disease caused by an increase in insulin resistance such as type II diabetes (NIDDM). The invention also relates to a method of reducing insulin resistance based on inhibiting the accumulation of chondroitin sulfate proteoglycan (CSPG) by administering a versican siRNA, C4ST-1 siRNA, C4ST-2 siRNA or C4ST-3 siRNA to a test subject and a method of treating or preventing a disease caused by an increase in insulin resistance such as type II diabetes utilizing the same.
Inventors:
YONEYAMA, Hiroyuki (STELIC INSTITUTE & CO. 9-15, Higashiazabu 1-chome, Minato-k, Tokyo 44, 1060044, JP)
Application Number:
JP2006/323657
Publication Date:
January 31, 2008
Filing Date:
November 28, 2006
Export Citation:
Assignee:
STELIC INSTITUTE OF REGENERATIVE MEDICINE, STELIC INSTITUTE & CO. (9-15, Higashiazabu 1-chome Minato-k, Tokyo 44, 1060044, JP)
株式会社ステリック再生医科学研究所 (〒44 東京都港区東麻布１丁目９番１５号 Tokyo, 1060044, JP)
株式会社ステリック再生医科学研究所 (〒44 東京都港区東麻布１丁目９番１５号 Tokyo, 1060044, JP)
International Classes:
A61K45/00; A61K31/7088; A61K38/43; A61P3/08; A61P3/10; C12Q1/00; G01N33/15; G01N33/50
Attorney, Agent or Firm:
SHIMIZU, Hatsushi et al. (Kantetsu Tsukuba Bldg. 6F, 1-1-1 Oroshi-machi, Tsuchiura-shi, Ibaraki 47, 3000847, JP)
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