Title:
INTEGRATED MODULAR ON-CHIP DROPLET MICROFLUIDIC SCREENING PLATFORM
Document Type and Number:
WIPO Patent Application WO/2019/148013
Kind Code:
A3
Abstract:
An automated fully integrated on-chip ultra-high-throughput droplet microfluidic screening platform (PolyChip) has been developed that integrates the cultivation and manipulation of cells (e.g., microbial) communities with "on the fly" sorting and analyses. The PolyChip system enables continuous operation of the entire process, from cell-encapsulated droplet generation, culture, merging with other cell-encapsulated droplets, culture, merging with reagent-laden droplets, culture, followed by detection and sorting.
Inventors:
GUZMAN ADRIAN (US)
HAN ARUM (US)
DE FIGUEIREDO PAUL (US)
HAN ARUM (US)
DE FIGUEIREDO PAUL (US)
Application Number:
PCT/US2019/015260
Publication Date:
September 26, 2019
Filing Date:
January 25, 2019
Export Citation:
Assignee:
TEXAS A & M UNIV SYS (US)
International Classes:
B01L3/00; C12M3/06
Foreign References:
| US20150232942A1 | 2015-08-20 | |||
| US20110059556A1 | 2011-03-10 | |||
| US20130260447A1 | 2013-10-03 |
Other References:
KIM, H. S. ET AL.: "A Droplet Microfluidics Platform for Rapid Microalgal Growth and Oil Production Analysis", BIOTECHNOL AND BIOENGINEERING, vol. 113, no. 8, August 2016 (2016-08-01), pages 1691 - 1701, XP055636147
KIM, H. S. ET AL.: "High-throughput droplet microfluidics screening platform for selecting fast-growing and high lipid-producing microalgae from a mutant library", PLANT DIRECT, vol. 1, e00011, September 2017 (2017-09-01), pages 1 - 13, XP055636150
KIM, H. S. ET AL.: "High-throughput droplet microfluidics screening platform for selecting fast-growing and high lipid-producing microalgae from a mutant library", PLANT DIRECT, vol. 1, e00011, September 2017 (2017-09-01), pages 1 - 13, XP055636150
Attorney, Agent or Firm:
RAMEY III, William P. et al. (US)
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