Title:
α1β1 INTEGRIN-DEPENDENT ENHANCEMENT CAR-MACROPHAGE, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/142635
Kind Code:
A1
Abstract:
Provided are an α1β1 integrin-dependent enhancement CAR-macrophage, a preparation method therefor and use thereof. The CAR-macrophage comprises an α1β1 integrin transmembrane region, an intracellular signal regulatory motif, an FcγRⅠ intracellular signal transduction motif, and an extracellular antigen-binding region having nucleotide sequences as set forth in SEQ ID NO: 1-4, respectively. According to the present invention, by designing a specific element applicable to the signal transduction function of macrophages, a CAR-macrophage technology platform is constructed in the true sense, the CAR-macrophage technology platform being widely applicable to a variety of applications and derivative designs for the treatment of solid tumors by CAR-macrophages.
Inventors:
NING PENGBO (CN)
Application Number:
PCT/CN2022/133793
Publication Date:
August 03, 2023
Filing Date:
November 23, 2022
Export Citation:
Assignee:
UNIV XIDIAN (CN)
International Classes:
C12N5/10; A61K39/00; A61P35/00; C07K19/00; C12N15/867
Foreign References:
| CN114410588A | 2022-04-29 | |||
| US20210046110A1 | 2021-02-18 | |||
| CN111733139A | 2020-10-02 | |||
| CN112236445A | 2021-01-15 | |||
| CN109790217A | 2019-05-21 | |||
| CN110684121A | 2020-01-14 | |||
| CN113106067A | 2021-07-13 | |||
| CN108025024A | 2018-05-11 |
Other References:
CHEN JIN, ZHANG CAI: "Chimeric Antigen Receptor-Modified Immune Cells and Their Application in Tumor Immunotherapy", CHINESE JOURNAL OF CANCER BIOTHERAPY, PUBLISHING HOUSE OF CHINESE JOURNAL OF CANCER BIOTHERAPY, CN, vol. 28, no. 6, 25 June 2021 (2021-06-25), CN , pages 549 - 557, XP093082212, ISSN: 1007-385X, DOI: 10.3872/j.issn.1007-385x.2021.06.001
CHEN YIZHAO, YU ZHIYING, TAN XUEWEN, JIANG HAIFENG, XU ZHEN, FANG YILONG, HAN DAFEI, HONG WENMING, WEI WEI, TU JIAJIE: "CAR-macrophage: A new immunotherapy candidate against solid tumors", BIOMEDICINE & PHARMACOTHERAPY, ELSEVIER, FR, vol. 139, 1 July 2021 (2021-07-01), FR , pages 111605, XP093005992, ISSN: 0753-3322, DOI: 10.1016/j.biopha.2021.111605
CHEN YIZHAO, YU ZHIYING, TAN XUEWEN, JIANG HAIFENG, XU ZHEN, FANG YILONG, HAN DAFEI, HONG WENMING, WEI WEI, TU JIAJIE: "CAR-macrophage: A new immunotherapy candidate against solid tumors", BIOMEDICINE & PHARMACOTHERAPY, ELSEVIER, FR, vol. 139, 1 July 2021 (2021-07-01), FR , pages 111605, XP093005992, ISSN: 0753-3322, DOI: 10.1016/j.biopha.2021.111605
Attorney, Agent or Firm:
BEIJING CHENGHUI LAW FIRM (CN)
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