Title:
INTEGRIN RECEPTOR-TARGETED ANTI-CANCER CONJUGATE
Document Type and Number:
WIPO Patent Application WO/2019/096095
Kind Code:
A1
Abstract:
Disclosed is a heptane sulfonate of a targeted drug conjugate modified by a multi-arm, water-soluble polymer. The typical heptane sulfonate of the conjugate comprises one to eight molecules of heptane sulfonate. Preferably, each branch respectively binds to a conjugate with two molecules of heptane sulfonate, and the preferred heptane sulfonate of the conjugate is eight molecules of heptane sulfonate. The present invention is a targeted anti-cancer conjugate modified by the multi-arm polymer, wherein modification by the water-soluble polymer can enhance the water solubility of the conjugate and increase a drug loading amount; and a targeting molecule enhances the targeting property, allowing the conjugate to be at a higher concentration in a target tissue.
Inventors:
YUAN JIANDONG (CN)
HUANG YANGQING (CN)
SONG YUNSONG (CN)
HUANG YANGQING (CN)
SONG YUNSONG (CN)
Application Number:
PCT/CN2018/115058
Publication Date:
May 23, 2019
Filing Date:
November 12, 2018
Export Citation:
Assignee:
BRIGHTGENE BIO MEDICAL TECH CO LTD (CN)
International Classes:
A61K47/64; A61K31/4745; A61K47/60; A61P35/00
Foreign References:
| CN107854693A | 2018-03-30 | |||
| CN108727583A | 2018-11-02 | |||
| CN102711836A | 2012-10-03 |
Other References:
HUANG, Y.Q. ET AL.: "Design, Synthesis and Pharmacological Evaluation of a Novel PEG-cRGD-conjugated Irinotecan Derivative as Potential Antitumor Agent", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 158, 31 August 2018 (2018-08-31) - 5 October 2018 (2018-10-05), pages 82 - 90, XP055610309
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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