Title:
INTELLIGENT CONTINUOUS MANUFACTURING METHOD VIA LIQUID COOLING OF DRIPPING PILLS
Document Type and Number:
WIPO Patent Application WO/2017/045609
Kind Code:
A1
Abstract:
An intelligent continuous manufacturing method via liquid cooling of dripping pills comprises the following steps: (1) feeding: weighing and transferring multiple materials respectively; (2) material combining: performing staged heating on the materials transferred in step (1), and mixing the same to obtain a material mixture, wherein an RSD of an effective ingredient in the material mixture ≤ 5%; (3) homogenizing: pressurizing the material mixture obtained in step (2), and increasing the temperature, so as to obtain a homogenized material having the RSD of the effective ingredient in the material mixture ≤ 5%; (4) dripping: performing vibration dripping on the homogenized material obtained in step (3) to obtain dripping pills, delivering the dripping pills into a cooling liquid to be cooled and then transferred; and (5) de-oiling: removing the cooling liquid on surfaces of the dripping pills obtained in step (4) via tilting centrifugation. The manufacturing method not only shortens the manufacturing process, but also ensures the dripping pill product to be more stable and homogeneous. In addition, high-speed centrifugation is used to reasonably de-oil the dripping pills to prevent contamination of the dripping pills and improve the circulation utilization rate of the cooling liquid.
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Inventors:
YAN KAIJING (CN)
SUN XIAOBING (CN)
RONG CHANGSHENG (CN)
CAI XUEFEI (CN)
WANG LIANG (CN)
SUN XIAOBING (CN)
RONG CHANGSHENG (CN)
CAI XUEFEI (CN)
WANG LIANG (CN)
Application Number:
PCT/CN2016/099018
Publication Date:
March 23, 2017
Filing Date:
September 14, 2016
Export Citation:
Assignee:
TASLY PHARMACEUTICAL GROUP CO (CN)
International Classes:
A61J3/06
Foreign References:
| CN104274322A | 2015-01-14 | |||
| CN101744722A | 2010-06-23 | |||
| CN104274518A | 2015-01-14 | |||
| CN101745472A | 2010-06-23 | |||
| CN104274319A | 2015-01-14 | |||
| TWM479758U | 2014-06-11 |
Other References:
See also references of EP 3351234A4
Attorney, Agent or Firm:
BEIJING JOYSHINE INTELLECTUAL PROPERTY OFFICE (CN)
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