INTERFEROMETRIC FOCUSING OF GUIDE-STARS FOR DIRECT WAVEFRONT SENSING

Title:

INTERFEROMETRIC FOCUSING OF GUIDE-STARS FOR DIRECT WAVEFRONT SENSING

Document Type and Number:

WIPO Patent Application WO/2014/152739

Kind Code:

A3

Abstract:

Interferometric focusing (IF), rather than conventional geometric focusing, of excitation light onto a guide-star that is embedded deeply in tissue, increases its fluorescence intensity. The method can extend the depth of wavefront measurement and improve correction inside of tissues because of its ability to suppress both scattering of diffuse light and aberration of ballistic light. The results showed more than two times improvement in SNR and RMS error of the wavefront measurement. Although only ballistic light in the excitation path is corrected, the intensity after wavefront correction increased by 1.5 times. When applying IF to a two-photon microscope with a near infra-red laser, this method would further extend the measurement depth and achieve high SNR for the wavefront sensor.

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Inventors:

TAO XIAODONG (US)
KUBBY JOEL A (US)

Application Number:

PCT/US2014/027680

Publication Date:

November 13, 2014

Filing Date:

March 14, 2014

Export Citation:

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Assignee:

UNIV CALIFORNIA (US)

International Classes:

F21V9/16

Foreign References:

US20130015367A1	2013-01-17
US20100105105A1	2010-04-29
US20060033933A1	2006-02-16
US20090137990A1	2009-05-28
US20040227101A1	2004-11-18

Attorney, Agent or Firm:

JACOBS, Ron et al. (Suite 300Palo Alto, CA, US)

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