Title:
INTERFERON MODULATOR, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/037755
Kind Code:
A1
Abstract:
The present invention relates to a compound represented by general formula (I), as well as a racemate, a stereoisomer, a tautomer, a polymorphic substance, and a solvate thereof, or a pharmaceutically acceptable salt thereof. The present invention further relates to a preparation method for the described compound represented by general formula (I), as well as a composition containing the same. The compound described by the present invention may be used to treat diseases caused by β interferon disorders, such as systemic lupus erythematosus, peripheral neuropathy, juvenile diabetes, autoimmune hemolytic anemia, ulcerative colitis, or rheumatoid arthritis and the like.
Inventors:
BAO HONGLI (CN)
XIONG HAIGEN (CN)
RAM KUMAR NAGARAJAN (CN)
QIAN BO (CN)
GE LIANG (CN)
JIAN WUJUN (CN)
FENG WEIWEI (CN)
XIONG HAIGEN (CN)
RAM KUMAR NAGARAJAN (CN)
QIAN BO (CN)
GE LIANG (CN)
JIAN WUJUN (CN)
FENG WEIWEI (CN)
Application Number:
PCT/CN2018/101899
Publication Date:
February 28, 2019
Filing Date:
August 23, 2018
Export Citation:
Assignee:
FUJIAN INST RES STR MATTER CAS (CN)
International Classes:
C07C247/12; C07B43/00; C07C247/02; C07C247/06; A61K31/02; A61K31/655; A61P37/02
Foreign References:
| CN104649857A | 2015-05-27 |
Other References:
INDRANIREKHA: "Catalyst-free Vicinal bromoazidation of olefins using TMSN3 and NBS", COMPTES RENDUS CHIMIE, vol. 15, no. 8, 12 June 2012 (2012-06-12), pages 688 - 692, XP055578034, ISSN: 1631-0748
ANIL: "A simple and efficient bromoazidation of alkenes using PTT and TMSN3 in ionic liquid", INDIAN JOURNAL OF CHEMISTRY, SECTION B: ORGANIC CHEMISTRY INCLUDING MEDICI- NAL CHEMISTRY, vol. 50B, 31 August 2011 (2011-08-31), pages 1123 - 1127, XP055578038, ISSN: 0376-4699
INDRANIREKHA SAIKIA: "Facile generation of vicinal bromoazides from ole- fins using TMSN3 and TsNBr2 without any catalyst", TETRAHEDRON LETTERS, vol. 50, no. 36, 16 June 2009 (2009-06-16), pages 5083 - 5087, XP026337630, ISSN: 0040-4039
SAUMEN: "Highly region- and stereoselective asymmetric bromoazida- tion of chiral a, beta -unsaturated carboxylic acid derivatives: scope and li- mitations", JOURNAL OF ORGANIC CHEMISTRY, vol. 71, no. 24, 27 October 2006 (2006-10-27), pages 9237 - 9240, ISSN: 0022-3263
JOSE: "A smooth and practicable azido-iodination reaction of alkenes based on IPy2BF4 and Me5SiN5", ADVANCED SYNTHESIS & CATALYSIS, vol. 343, no. 4, 8 June 2001 (2001-06-08), pages 335 - 337, XP055578047
ANIL: "A simple and efficient bromoazidation of alkenes using PTT and TMSN3 in ionic liquid", INDIAN JOURNAL OF CHEMISTRY, SECTION B: ORGANIC CHEMISTRY INCLUDING MEDICI- NAL CHEMISTRY, vol. 50B, 31 August 2011 (2011-08-31), pages 1123 - 1127, XP055578038, ISSN: 0376-4699
INDRANIREKHA SAIKIA: "Facile generation of vicinal bromoazides from ole- fins using TMSN3 and TsNBr2 without any catalyst", TETRAHEDRON LETTERS, vol. 50, no. 36, 16 June 2009 (2009-06-16), pages 5083 - 5087, XP026337630, ISSN: 0040-4039
SAUMEN: "Highly region- and stereoselective asymmetric bromoazida- tion of chiral a, beta -unsaturated carboxylic acid derivatives: scope and li- mitations", JOURNAL OF ORGANIC CHEMISTRY, vol. 71, no. 24, 27 October 2006 (2006-10-27), pages 9237 - 9240, ISSN: 0022-3263
JOSE: "A smooth and practicable azido-iodination reaction of alkenes based on IPy2BF4 and Me5SiN5", ADVANCED SYNTHESIS & CATALYSIS, vol. 343, no. 4, 8 June 2001 (2001-06-08), pages 335 - 337, XP055578047
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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