INTERHETEROARYL 7-OXABICYCLIC [2.2.1]HEPTANE OXAZOLES AS PROSTAGLANDIN F ANTAGONISTS

Title:

INTERHETEROARYL 7-OXABICYCLIC [2.2.1]HEPTANE OXAZOLES AS PROSTAGLANDIN F ANTAGONISTS

Document Type and Number:

WIPO Patent Application WO2002022620

Kind Code:

A3

Abstract:

The present invention provides novel compounds represented by the general formula (I). The novel compounds are PGF2a antagonists, useful in pharmaceutical compositions for treating PGF2a-mediated disease responses such as inflammatory reactions relating to rheumatoid arthritis and psoriasis, reproductive disorders, bronchoconstrictive disorders (asthma), excessive bone breakdown (osteoporosis), peptic ulcers, heart disease, platelet aggregation and thrombosis.

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Inventors:

BURK ROBERT M
DONDE YARIV

Application Number:

PCT/US2001/028174

Publication Date:

August 29, 2002

Filing Date:

September 07, 2001

Export Citation:

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Assignee:

ALLERGAN SALES INC (US)

International Classes:

A61K31/422; A61P1/04; A61P7/02; A61P9/04; A61P11/06; A61P15/00; A61P17/06; A61P19/02; A61P19/10; A61P29/00; A61P43/00; C07D493/08; (IPC1-7): C07D493/08; A61K31/34; A61K31/422; A61P1/04

Foreign References:

US5100889A

1992-03-31

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