Title:
INTERLEUKIN 15 PROTEIN COMPLEX AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/095642
Kind Code:
A9
Abstract:
Provided in the application is a interleukin 15 (IL-15) protein complex. The IL-15 protein complex consists of a soluble fusion proteins (I) and (II), wherein the fusion protein (I) is a IL-15 polypeptide or a functionality fragment thereof, and the fusion protein (II) is a IL-15Rα polypeptide or a functionality fragment thereof. There are one or more amino acid sites on the fusion proteins (I) or (II) were mutated to Cys, which were paired with the corresponding Cys mutated from the amino acid sites on the fusion proteins (II) or(I) to form disulfide bonds. The IL-15 protein complex can be used for tumour therapy.
Inventors:
QU XIANGDONG (CN)
YE XIN (CN)
HU QIYUE (CN)
CUI DONGBING (CN)
TAO WEIKANG (CN)
ZHANG LIANSHAN (CN)
SUN PIAOYANG (CN)
YE XIN (CN)
HU QIYUE (CN)
CUI DONGBING (CN)
TAO WEIKANG (CN)
ZHANG LIANSHAN (CN)
SUN PIAOYANG (CN)
Application Number:
PCT/CN2015/094780
Publication Date:
October 20, 2016
Filing Date:
November 17, 2015
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K19/00; A61K38/20; A61P1/00; A61P7/00; A61P17/00; A61P19/02; A61P29/00; A61P31/00; A61P35/00; A61P37/02; C12N15/62
Attorney, Agent or Firm:
GE CHENG & CO.,LTD. (CN)
北京戈程知识产权代理有限公司 (CN)
北京戈程知识产权代理有限公司 (CN)
Download PDF: