Title:
INTERLEUKIN-2 MUTANT AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/185361
Kind Code:
A1
Abstract:
The present invention provides an interleukin-2 (IL-2) mutant protein. Also provided are a fusion protein, dimer molecule, and immunoconjugate containing the IL-2 mutant protein, a nucleic acid encoding same, a vector and host cell containing the nucleic acid, as well as a pharmaceutical composition containing same and therapeutic use. The present invention further provides a method for preparing the IL-2 mutant protein, fusion protein, dimer molecule, and immunoconjugate.
Inventors:
HE KAIJIE (CN)
FU FENGGEN (CN)
ZHOU SHUAIXIANG (CN)
WU WEIWEI (CN)
FU FENGGEN (CN)
ZHOU SHUAIXIANG (CN)
WU WEIWEI (CN)
Application Number:
PCT/CN2021/081840
Publication Date:
September 23, 2021
Filing Date:
March 19, 2021
Export Citation:
Assignee:
INNOVENT BIOLOGICS SUZHOU CO LTD (CN)
International Classes:
C07K14/55; A61K38/20; A61P35/00; A61P37/00; C07K19/00; C12N5/10; C12N15/26; C12N15/62; C12N15/63
Domestic Patent References:
| WO2019246404A1 | 2019-12-26 | |||
| WO1991002000A1 | 1991-02-21 |
Foreign References:
| CN103492411A | 2014-01-01 | |||
| CN1309705A | 2001-08-22 | |||
| CN2019107054W | 2019-09-20 | |||
| CN2019107055W | 2019-09-20 | |||
| US4518584A | 1985-05-21 |
Other References:
"NCBI", Database accession no. NP517425
SMITH, SCIENCE, vol. 240, 1988, pages 1169 - 76
BAZAN, SCIENCE, vol. 257, 1992, pages 410 - 413
KRIEG ET AL., PROC NATL ACAD SCI, vol. 107, 2010, pages 11906 - 11
BYMAN, O.SPRENT. J., NAT. REV. IMMUNOL., vol. 12, 2012, pages 180 - 190
FONTENOT ET AL., NATURE IMMUNOL, vol. 6, 2005, pages 1171 - 72
RODRIGO VAZQUEZ-LOMBARDI ET AL., NATURE COMMUNICATIONS, vol. 8, pages 15373
ALTSCHUL ET AL., NUC. ACIDS RES, vol. 25, 1977, pages 3389 - 402
ALTSCHUL ET AL., J.MOL. BIOL., vol. 215, 1990, pages 403 - 10
GESTUR VIDARSSON ET AL., IGG SUBCLASSES AND ALLOTYPES: FROM STRUCTURE TO EFFECTOR FUNCTIONS, 20 October 2014 (2014-10-20)
KABAT, E.A. ET AL.: "Sequences of Proteins of Immunological Interest", 1991, NIH PUBLICATION, pages: 91 - 3242
ERIC J., SMITH, SCIENTIFIC REPORTS, vol. 5, pages 17943
GRAHAM ET AL., JGENVIROL, vol. 36, 1977, pages 59
MATHER, BIOLREPROD, vol. 23, 1980, pages 243 - 251
MATHER ET AL., ANNALSNYACADSCI, vol. 383, 1982, pages 44 - 68
URLAUB ET AL., PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4216
ESTEP, P ET AL.: "High throughput solution Based measurement of antibody-antigen affinity and epitope binding", MABS, vol. 5, no. 2, 2013, pages 270 - 8, XP055105281, DOI: 10.4161/mabs.23049
See also references of EP 4122952A1
SMITH, SCIENCE, vol. 240, 1988, pages 1169 - 76
BAZAN, SCIENCE, vol. 257, 1992, pages 410 - 413
KRIEG ET AL., PROC NATL ACAD SCI, vol. 107, 2010, pages 11906 - 11
BYMAN, O.SPRENT. J., NAT. REV. IMMUNOL., vol. 12, 2012, pages 180 - 190
FONTENOT ET AL., NATURE IMMUNOL, vol. 6, 2005, pages 1171 - 72
RODRIGO VAZQUEZ-LOMBARDI ET AL., NATURE COMMUNICATIONS, vol. 8, pages 15373
ALTSCHUL ET AL., NUC. ACIDS RES, vol. 25, 1977, pages 3389 - 402
ALTSCHUL ET AL., J.MOL. BIOL., vol. 215, 1990, pages 403 - 10
GESTUR VIDARSSON ET AL., IGG SUBCLASSES AND ALLOTYPES: FROM STRUCTURE TO EFFECTOR FUNCTIONS, 20 October 2014 (2014-10-20)
KABAT, E.A. ET AL.: "Sequences of Proteins of Immunological Interest", 1991, NIH PUBLICATION, pages: 91 - 3242
ERIC J., SMITH, SCIENTIFIC REPORTS, vol. 5, pages 17943
GRAHAM ET AL., JGENVIROL, vol. 36, 1977, pages 59
MATHER, BIOLREPROD, vol. 23, 1980, pages 243 - 251
MATHER ET AL., ANNALSNYACADSCI, vol. 383, 1982, pages 44 - 68
URLAUB ET AL., PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4216
ESTEP, P ET AL.: "High throughput solution Based measurement of antibody-antigen affinity and epitope binding", MABS, vol. 5, no. 2, 2013, pages 270 - 8, XP055105281, DOI: 10.4161/mabs.23049
See also references of EP 4122952A1
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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