Title:
INTERLEUKIN-31 MONOCLONAL ANTIBODIES FOR VETERINARY USE
Document Type and Number:
WIPO Patent Application WO/2019/177697
Kind Code:
A3
Abstract:
A monoclonal antibody, or antigen-binding portion thereof is provided that specifically binds to a region on a mammalian IL-31 protein involved with interaction of the IL-31 protein with its co-receptor, wherein the binding of said antibody to said region is impacted by mutations in a 15H05 epitope binding region selected from: a region between about amino acid residues (124 and 135) of a feline IL-31 sequence represented by SEQ ID NO: 157 (Feline_IL31_wildtype); a region between about amino acid residues (124 and 135) of a canine IL-31 sequence represented by SEQ ID NO: 155 (Canine_IL31); and a region between about amino acid residues (118 and 129) of an equine IL-31 sequence represented by SEQ ID NO: 165 (Equine_IL31). Such antibodies can be in the form of veterinary compositions useful for treating IL-31 -mediated disorders in cats, dogs, or horses.
Inventors:
BAMMERT GARY FRANCIS (US)
DUNHAM STEVEN ALAN (US)
STEINIGER SEBASTIAN C (US)
DUNHAM STEVEN ALAN (US)
STEINIGER SEBASTIAN C (US)
Application Number:
PCT/US2019/014885
Publication Date:
October 31, 2019
Filing Date:
January 24, 2019
Export Citation:
Assignee:
ZOETIS SERVICES LLC (US)
International Classes:
C07K16/24; A61K39/00; A61P17/00; A61P35/00; A61P37/00
Domestic Patent References:
| WO2018162577A1 | 2018-09-13 | |||
| WO2017042212A1 | 2017-03-16 | |||
| WO2013184871A1 | 2013-12-12 |
Foreign References:
| US20130022616A1 | 2013-01-24 | |||
| US20090252732A1 | 2009-10-08 |
Other References:
GINA M. MICHELS ET AL: "A blinded, randomized, placebo-controlled, dose determination trial of lokivetmab (ZTS-00103289), a caninized, anti-canine IL-31 monoclonal antibody in client owned dogs with atopic dermatitis", VETERINARY DERMATOLOGY., vol. 27, no. 6, 1 December 2016 (2016-12-01), GB, pages 478 - e129, XP055397044, ISSN: 0959-4493, DOI: 10.1111/vde.12376
M. FURUE ET AL: "Emerging role of interleukin-31 and interleukin-31 receptor in pruritus in atopic dermatitis", ALLERGY, vol. 73, no. 1, 20 July 2017 (2017-07-20), United Kingdom, pages 29 - 36, XP055588801, ISSN: 0105-4538, DOI: 10.1111/all.13239
M. FURUE ET AL: "Emerging role of interleukin-31 and interleukin-31 receptor in pruritus in atopic dermatitis", ALLERGY, vol. 73, no. 1, 20 July 2017 (2017-07-20), United Kingdom, pages 29 - 36, XP055588801, ISSN: 0105-4538, DOI: 10.1111/all.13239
Attorney, Agent or Firm:
SZAKIEL, Gloria K. et al. (US)
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