INTERMEDIATE FOR 2-SUBSTITUTED CARBAPENEM DERIVATIVE AND PRODUCTION PROCESS

Title:

INTERMEDIATE FOR 2-SUBSTITUTED CARBAPENEM DERIVATIVE AND PRODUCTION PROCESS

Document Type and Number:

WIPO Patent Application WO/2004/055027

Kind Code:

A1

Abstract:

A compound represented by the following formula (1) and a process for producing the compound. From this compound, a carbapenem derivative which has excellent antibacterial activity and is effective against a wide spectrum of bacteria can be safely and inexpensively produced. (1) [In the formula, R¹ represents hydrogen or a hydroxy-protecting group; R² represents hydrogen, a carboxy-protecting group, or a carboxylic acid anion; Z¹ and Z² in combination represent oxygen or a carbonyl-protecting group, or one of Z¹ and Z² represents hydrogen and the other represents hydroxy or a protected hydroxy group; and Y represents oxygen or a group represented by P(R³)₃ (wherein R³'s may be the same or different and each represents optionally halogenated C_1-6 alkyl or aryl optionally substituted by halogeno or C_1-6 alkyl (the alkyl may have been substituted by halogeno).]

Inventors:

SASAKI TOSHIRO (JP)
ANDO TAKASHI (JP)
YAMAMOTO YASUO (JP)
IMAI TAKAHIRO (JP)
KUBOTA DAI (JP)
NOGUCHI KATSUHIKO (JP)
HORI NOBUYUKI (JP)
SHITARA EIKI (JP)
ATSUMI KUNIO (JP)
YASUDA SHOHEI (JP)

Application Number:

PCT/JP2003/016036

Publication Date:

July 01, 2004

Filing Date:

December 15, 2003

Export Citation:

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Assignee:

MEIJI SEIKA KAISHA (JP)
SASAKI TOSHIRO (JP)
ANDO TAKASHI (JP)
YAMAMOTO YASUO (JP)
IMAI TAKAHIRO (JP)
KUBOTA DAI (JP)
NOGUCHI KATSUHIKO (JP)
HORI NOBUYUKI (JP)
SHITARA EIKI (JP)
ATSUMI KUNIO (JP)
YASUDA SHOHEI (JP)

International Classes:

C07D513/04; C07D519/06; C07F9/6561; (IPC1-7): C07D513/04; C07D519/06; C07F9/6561

Domestic Patent References:

WO2002042312A1	2002-05-30
WO2001053305A1	2001-07-26

Foreign References:

JPH08311071A	1996-11-26
JP2003026686A	2003-01-29

Other References: