Title:
INTERMEDIATE FOR PREPARING ERIBULIN MESYLATE AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2019/093776
Kind Code:
A1
Abstract:
The present invention relates to a method for preparing a high-yield and high-purity compound of chemical formula 6, which is an intermediate for preparing eribulin mesylate, and to an intermediate therefor.
Inventors:
SHIN HYUNIK (KR)
LEE KEEYOUNG (KR)
OH CHANGYOUNG (KR)
LEE KEEYOUNG (KR)
OH CHANGYOUNG (KR)
Application Number:
PCT/KR2018/013510
Publication Date:
May 16, 2019
Filing Date:
November 08, 2018
Export Citation:
Assignee:
YONSUNG FINE CHEMICAL CO LTD (KR)
International Classes:
C07D307/12; A61K31/357; C07D493/22
Domestic Patent References:
| WO2006076100A2 | 2006-07-20 |
Foreign References:
| US6365759B1 | 2002-04-02 | |||
| US7982060B2 | 2011-07-19 | |||
| US6214865B1 | 2001-04-10 | |||
| US7982060B2 | 2011-07-19 |
Other References:
AUSTAD, B. C.: "Process development of Halaven: Synthesis of the C14-C35 fragment via iterative Nozaki-Hiyama-Kishi reaction-Williamson ether cyclization", SYNLETT, 2013, pages 327 - 332, XP055241629, DOI: doi:10.1055/s-0032-1317920
PRABHAKAR, P. ET AL.: "A mild and efficient chemoselective protection of primary alcohols as pivaloyl esters using La(N03)3.6H20 as a catalyst under solvent- free conditions", CHEMISTRY LETTERS, vol. 36, no. 6, 3 May 2007 (2007-05-03), pages 732 - 733, XP055606900
PRABHAKAR, P. ET AL.: "A mild and efficient chemoselective protection of primary alcohols as pivaloyl esters using La(N03)3.6H20 as a catalyst under solvent- free conditions", CHEMISTRY LETTERS, vol. 36, no. 6, 3 May 2007 (2007-05-03), pages 732 - 733, XP055606900
Attorney, Agent or Firm:
YU, Su Mi (KR)
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