Title:
INTERMEDIATES FOR EPOTHILONE DERIVATIVE AND PROCESS FOR PRODUCING THESE
Document Type and Number:
WIPO Patent Application WO/2003/029195
Kind Code:
A1
Abstract:
Acetonides of a ß−keto ester compound, ß−hydroxyacid compound, and 1,3−diol derivative respectively represented by the following formulae (I), (V), and (VIII): (I) (V) (VIII) (wherein the symbols are the same as defined in the description). The acetonides are useful as intermediates for an epothilone derivative which is being developed as a drug having antitumor activity.
Inventors:
IWASAKI MITSUHIRO
SUGI KIYOSHI
MIYAMOTO HIDEHITO
ITAYA NOBUSHIGE
SUGI KIYOSHI
MIYAMOTO HIDEHITO
ITAYA NOBUSHIGE
Application Number:
PCT/JP2002/010089
Publication Date:
April 10, 2003
Filing Date:
September 27, 2002
Export Citation:
Assignee:
SUMIKA FINE CHEMICALS CO LTD (JP)
International Classes:
C07C253/30; C07C255/21; C07D319/06; C07D417/06; C07D493/04; C07C255/12; C07C255/20; (IPC1-7): C07C255/21; C07C255/20; C07C253/30; C07C253/34; C07C255/15; C07D319/06
Foreign References:
| US20020156289A1 | 2002-10-24 |
Other References:
BODE J.W. ET AL.: "Stereoselective syntheses of epothilones A and B via nitrile oxide cycloadditions and related studies", J. ORG. CHEM., vol. 66, no. 19, 21 September 2001 (2001-09-21), pages 6410 - 6424, XP002960449
Attorney, Agent or Firm:
Takashima, Hajime (2-14 Fushimimachi 4-chome, Chuo-k, Osaka-shi Osaka, JP)
Download PDF: