Title:
INTERMEDIATES FOR THE PREPARATION OF HMG-COA REDUCTASE INHIBITORS AND PROCESSES FOR THE PREPARATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/104725
Kind Code:
A3
Abstract:
A compound of general Formula (1), is disclosed wherein P1 and P2 are alcohol protecting groups or 1,3-diol protecting group, R is: (a) or (b) or (c) wherein R4a is alkyl, aryl, arylalkyl or cycloalkyl, Rc is H, alkyl, aryl, alkaoxy, haloalkyl, monohaloalkyloxy, dihaloalkyloxy, Rd is alkyl, aryl, arylalkyl, CF3, halo or NO2 and X is O, N-H, N-alkyl or S, Ra and Rb may be same or different and each represents hydrogen, an alkyl group of 1 to 12 carbon atoms, an aryl group of 6 to 12 carbon atoms, or an aralkyl group of 7 to 12 carbon atoms.
Inventors:
DWIVEDI SHRIPRAKASH DHAR (IN)
PATEL DHIMANT JASUBHAI (IN)
RUPAPARA MAHESH LALJIBHAI (IN)
PATEL DHIMANT JASUBHAI (IN)
RUPAPARA MAHESH LALJIBHAI (IN)
Application Number:
PCT/IN2011/000108
Publication Date:
November 03, 2011
Filing Date:
February 23, 2011
Export Citation:
Assignee:
CADILA HEALTHCARE LTD (IN)
DWIVEDI SHRIPRAKASH DHAR (IN)
PATEL DHIMANT JASUBHAI (IN)
RUPAPARA MAHESH LALJIBHAI (IN)
DWIVEDI SHRIPRAKASH DHAR (IN)
PATEL DHIMANT JASUBHAI (IN)
RUPAPARA MAHESH LALJIBHAI (IN)
International Classes:
C07D239/42; C07D257/04; C07D405/12
Domestic Patent References:
| WO2008044243A2 | 2008-04-17 | |||
| WO2007125547A2 | 2007-11-08 | |||
| WO2007000121A1 | 2007-01-04 | |||
| WO2003064392A1 | 2003-08-07 |
Other References:
BAKER-GLENN, C. ET AL: "A biocatalytic route to enantioenriched, sulfanyl aldol products", TETRAHEDRON, vol. 60, no. 35, 2004, pages 7607 - 7619, XP002650028
HAYAKAWA, RYUUICHIROU ET AL: "Ethyl (R)-3-hydroxy-4-phenylthiobutyrate: synthesis by the bakers' yeast reduction and use as a precursor of enantiomerically pure .beta.-lactam", TETRAHEDRON LETTERS, vol. 37, no. 42, 1996, pages 7533 - 7536, XP002650029
HAYAKAWA, RYUUICHIROU ET AL: "Ethyl (R)-3-hydroxy-4-phenylthiobutyrate: synthesis by the bakers' yeast reduction and use as a precursor of enantiomerically pure .beta.-lactam", TETRAHEDRON LETTERS, vol. 37, no. 42, 1996, pages 7533 - 7536, XP002650029
Attorney, Agent or Firm:
SUBRAMANIAM, Hariharan (Nataraj & AssociatesE- 556, Greater Kailash-II, New Delhi 8, IN)
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