INTERMEDIATES USEFUL IN PRODUCING CARBAPENEM AND PROCESS FOR THE STEREOSELECTIVE PRODUCTION OF THE SAME

Title:

INTERMEDIATES USEFUL IN PRODUCING CARBAPENEM AND PROCESS FOR THE STEREOSELECTIVE PRODUCTION OF THE SAME

Document Type and Number:

WIPO Patent Application WO/1998/052918

Kind Code:

A1

Abstract:

An efficient process for the stereoselective production of (2S,4S)-2-[[(R)-hydroxy-(3R)-cyclic amin-3-yl]methyl]pyrrolidine-4-thiol or its salts, which are intermediates useful in producing carbapenem, by reacting a compound represented by general formula (I) (wherein R?1� represents lower alkylsulfonyl, optionally substituted arylsulfonyl or alkylsilyl; and R?2� represents an amino-protective group) with a compound represented by general formula (II), wherein R?3� represents optionally substituted lower alkyl or aryl; X represents oxygen or sulfur; Y represents azido or nitro; and m is an integer of from 2 to 5.

Inventors:

SUZUKI TAKAAKI (JP)
SUGIYAMA ISAO (JP)
SASHO MANABU (JP)
SATO NOBUAKI (JP)
KAMADA ATSUSHI (JP)
ASHIZAWA KAZUHIDE (JP)

Application Number:

PCT/JP1998/002225

Publication Date:

November 26, 1998

Filing Date:

May 21, 1998

Export Citation:

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Assignee:

EISAI CO LTD (JP)
SUZUKI TAKAAKI (JP)
SUGIYAMA ISAO (JP)
SASHO MANABU (JP)
SATO NOBUAKI (JP)
KAMADA ATSUSHI (JP)
ASHIZAWA KAZUHIDE (JP)

International Classes:

C07D207/12; C07D263/22; C07D413/06; C07D477/20; (IPC1-7): C07D207/26; C07D207/27; C07D413/06; C07D417/06

Foreign References:

JPH0873462A

1996-03-19

Other References: