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Title:
INTESTINAL BARRIER FUNCTION-ENHANCING COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2019/131759
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: an intestinal barrier function-enhancing composition capable of enhancing intestinal barrier function; and an agent for enhancing the intestinal barrier function of gallic acid. The present invention pertains to an intestinal barrier function-enhancing composition containing gallic acid as an active ingredient.

Inventors:
FUNAKI AYUTA (JP)
KASAJIMA NAOKI (JP)
ARIE HIDEYUKI (JP)
Application Number:
PCT/JP2018/047840
Publication Date:
July 04, 2019
Filing Date:
December 26, 2018
Export Citation:
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Assignee:
SUNTORY HOLDINGS LTD (JP)
International Classes:
A23L33/10; A61K31/05; A61K31/12; A61K31/192; A61K31/353; A61K31/7024; A61K31/7034; A61K31/7048; A61P1/00; A61P3/00; A61P9/10; A61P37/02; A61P43/00
Domestic Patent References:
WO2002009734A12002-02-07
Foreign References:
JP2010503609A2010-02-04
JP2011514347A2011-05-06
JP2004262905A2004-09-24
JP2011084543A2011-04-28
Other References:
ABIODUN, O. O. ET AL.: "Antiinflammatory and immunomodulatory activity of an ethanolic extract from the stem bark of Terminalia catappa L. (Combretaceae) : In vitro and in vivo evidences", JOURNAL OF ETHNOPHARMACOLOGY, vol. 192, 21 July 2016 (2016-07-21), pages 309 - 319, XP029763365
XUAN, Y. ET AL.: "Pomegranate leaf attenuates lipid absorption in the small intestine in hyperlipidemic mice by inhibiting lipase activity", CHINESE JOURNAL OF NATURAL MEDICINES, vol. 15, no. 10, 2017, pages 732 - 739, XP085279163
PARK, H. Y. ET AL.: "Theaflavins enhance intestinal barrier of Caco-2 Cell monolayers through the expression of AMP-activated protein kinase-mediated Occludin, claudin-1, and ZO-1", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, vol. 79, no. 1, 30 August 2014 (2014-08-30) - 2015, pages 130 - 137, XP055623330
ROGOLL, D. ET AL.: "Influence of apple polyphenols on the intestinal barrier in a colonic cell model", JOURNAL OF APPLIED BOTANY AND FOOD QUALITY, vol. 83, no. 2, 2010 - 5 December 2012 (2012-12-05), pages 110 - 117, XP055623335
CREMONINI, E. ET AL.: "Anthocyanins inhibit tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity", FOOD & FUNCTION, vol. 8, no. 8, 18 July 2017 (2017-07-18) - 1 August 2017 (2017-08-01), pages 2915 - 2923, XP055623342
Attorney, Agent or Firm:
YASUTOMI & ASSOCIATES (JP)
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