Title:
INTESTINAL ENVIRONMENT-IMPROVING AGENT
Document Type and Number:
WIPO Patent Application WO/2017/221886
Kind Code:
A1
Abstract:
Provided are an intestinal environment-improving agent containing as an active ingredient a compound represented by formula [I] or a pharmaceutically acceptable salt thereof, and a novel medicine useful in the prevention or treatment of conditions such as hepatic encephalopathy and uremia.
Inventors:
IO FUSAYO (JP)
YAMAMOTO DAISUKE (JP)
YAMAMOTO KOJI (JP)
YAMAMOTO DAISUKE (JP)
YAMAMOTO KOJI (JP)
Application Number:
PCT/JP2017/022514
Publication Date:
December 28, 2017
Filing Date:
June 19, 2017
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K31/351; A61P1/00; A61P1/16; A61P13/12; A61P25/00
Domestic Patent References:
| WO2014119787A1 | 2014-08-07 | |||
| WO2012023598A1 | 2012-02-23 |
Foreign References:
| JP2012518631A | 2012-08-16 |
Other References:
FUKASHI IMAI ET AL.: "Kanshikkan to Daicho Ijo", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 46, no. 2, 1988, pages 457 - 462, ISSN: 0047-1852
HIROSHI NAKAMURA: "Indican", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 67, no. Suppl. 8, 2009, pages 161 - 164, ISSN: 0047-1852
TAKAHIRO MATSUKI ET AL.: "Tonyobyo Kanja no Chonai Flora to a-Glucosidase Sogaiyaku ga Oyobosu Eikyo ni Tsuite no Kento", THE JOURNAL OF THE JAPAN DIABETIC SOCIETY, vol. 48, no. Suppl. 2, 25 April 2005 (2005-04-25), pages S-266, ISSN: 0021-437X
GYOKAI RUPO KIGYO: "Salacia-zoku Shokubutsu no Kenko ni Oyobosu Sayo Tokyo Symposium de Kenkyu Seika o Happyo", THE FOOD INDUSTRY, vol. 52, no. 1, 2009, pages 22 - 25, ISSN: 0559-8990
SHINZO NODA: "Kuwa DNJ no Atarashii Kinosei", FOOD PROCESSING AND INGREDIENTS, vol. 33, no. 8, 1998, pages 42 - 44, ISSN: 0911-3932
HOLTE, K. ET AL.: "Systematic review and meta-analysis of randomized trials on probiotics for hepatic encephalopathy", HEPATOLOGY RESEARCH, vol. 42, no. 10, 2012, pages 1008 - 1015, XP055446407
VITETTA, L. ET AL.: "Uremia and chronic kidney disease: The role of the gut microflora and therapies with pro- and prebiotics", MOLECULAR NUTRITION & FOOD RESEARCH, vol. 57, no. 5, 2013, pages 824 - 832, XP055446408, ISSN: 1613-4125
HORNBY, P. J.: "SGLT1 inhibition has modest gastrointestinal consequences in mice and rats", FASEB JOURNAL, vol. 31, no. 1, April 2017 (2017-04-01), pages 1, XP055446412
HIROSHI NAKAMURA: "Indican", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 67, no. Suppl. 8, 2009, pages 161 - 164, ISSN: 0047-1852
TAKAHIRO MATSUKI ET AL.: "Tonyobyo Kanja no Chonai Flora to a-Glucosidase Sogaiyaku ga Oyobosu Eikyo ni Tsuite no Kento", THE JOURNAL OF THE JAPAN DIABETIC SOCIETY, vol. 48, no. Suppl. 2, 25 April 2005 (2005-04-25), pages S-266, ISSN: 0021-437X
GYOKAI RUPO KIGYO: "Salacia-zoku Shokubutsu no Kenko ni Oyobosu Sayo Tokyo Symposium de Kenkyu Seika o Happyo", THE FOOD INDUSTRY, vol. 52, no. 1, 2009, pages 22 - 25, ISSN: 0559-8990
SHINZO NODA: "Kuwa DNJ no Atarashii Kinosei", FOOD PROCESSING AND INGREDIENTS, vol. 33, no. 8, 1998, pages 42 - 44, ISSN: 0911-3932
HOLTE, K. ET AL.: "Systematic review and meta-analysis of randomized trials on probiotics for hepatic encephalopathy", HEPATOLOGY RESEARCH, vol. 42, no. 10, 2012, pages 1008 - 1015, XP055446407
VITETTA, L. ET AL.: "Uremia and chronic kidney disease: The role of the gut microflora and therapies with pro- and prebiotics", MOLECULAR NUTRITION & FOOD RESEARCH, vol. 57, no. 5, 2013, pages 824 - 832, XP055446408, ISSN: 1613-4125
HORNBY, P. J.: "SGLT1 inhibition has modest gastrointestinal consequences in mice and rats", FASEB JOURNAL, vol. 31, no. 1, April 2017 (2017-04-01), pages 1, XP055446412
Attorney, Agent or Firm:
ONO, SHINJIRO et al. (JP)
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