Title:
INTESTINAL FIBROSIS TREATMENT AGENT
Document Type and Number:
WIPO Patent Application WO/2013/073667
Kind Code:
A1
Abstract:
The present invention pertains to a material delivery carrier for extracellular matrix-producing cells in the intestines, the carrier comprising a retinoid as a targeting agent, as well as to an intestinal fibrosis treatment agent using the carrier.
Inventors:
AYABE TOKIYOSHI (JP)
NAKAMURA KIMINORI (JP)
MINOMI KENJIRO (JP)
TANAKA YASUNOBU (JP)
NAKAMURA KIMINORI (JP)
MINOMI KENJIRO (JP)
TANAKA YASUNOBU (JP)
Application Number:
PCT/JP2012/079783
Publication Date:
May 23, 2013
Filing Date:
November 16, 2012
Export Citation:
Assignee:
NITTO DENKO CORP (JP)
International Classes:
A61K47/10; A61K45/08; A61P1/04; C12N5/071; C12N15/09; G01N33/15; G01N33/50; A61K9/127; A61K31/713
Domestic Patent References:
| WO2006068232A1 | 2006-06-29 | |||
| WO2010014117A1 | 2010-02-04 | |||
| WO2008022807A2 | 2008-02-28 | |||
| WO2009084232A1 | 2009-07-09 | |||
| WO2006068232A1 | 2006-06-29 | |||
| WO2009036368A2 | 2009-03-19 | |||
| WO2010014117A1 | 2010-02-04 | |||
| WO2009116257A1 | 2009-09-24 | |||
| WO2010026766A1 | 2010-03-11 |
Foreign References:
| JP2010539245A | 2010-12-16 | |||
| JP2010059124A | 2010-03-18 | |||
| JP2009221164A | 2009-10-01 |
Other References:
YOSHIRO NIITSU: "Kansei Saibo o Hyoteki to shita Kankohen no Chiryo Senryaku", EXPERIMENTAL MEDICINE, vol. 29, no. 13, August 2011 (2011-08-01), pages 2114 - 2122, XP008172815
YOSHIRO NIITSU: "Treatment of Organ Fibrosis by siRNAHSP47", IBN SEMINAR SERIES: TREATMENT OF ORGAN FIBROSIS BY SIRNAHSP47, 2010, JAPAN, XP055146428, Retrieved from the Internet
YOSHIRO NIITSU: "Zoki Sen'isho Chiryo no Shintenkai", THE JOURNAL OF THE JAPANESE RESPIRATORY SOCIETY 1343-3490, vol. 47, no. SUPPL., 2009, pages 67, XP008172636
KIDD, M. ET AL.: "CTGF, intestinal stellate cells and carcinoid fibrogenesis", WORLD J GASTROENTEROL, vol. 13, no. 39, 2007, pages 5208 - 16, XP055144306
HIROSHI NAGANUMA ET AL.: "Shocho Kanmaku yori Hassei shi, Shinkeikei eno Bunka o Shimeshita Akusei Ichokangai Kanshitsu Shuyo no Ichirei", SENDAI SHIRITSU BYOIN IGAKU ZASSHI, vol. 27, 25 June 2007 (2007-06-25), pages 51 - 57, XP008172822, Retrieved from the Internet
KOJI KUBOTA ET AL.: "A Case of Gastrointestinal Stromal Tumor of the Mesentery", JAPANESE JOURNAL OF GASTROENTEROLOGICAL SURGERY, vol. 41, no. 4, 1 April 2008 (2008-04-01), pages 435 - 440, XP055144318, Retrieved from the Internet
SAWAKO YOSHIOKA ET AL.: "Identification of stellate cells in the mouse small intestine", DAI 32 KAI ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN, 11 December 2009 (2009-12-11), pages 240, XP008172820
SAWAKO YOSHIOKA ET AL.: "Isolation of intermediate stellate cells in the mouse small intestine", DAI 33 KAI ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN, 10 December 2010 (2010-12-10), XP008172637
RIEDER; FIOCCHI, NAT REV GASTROENTEROL HEPATOL., vol. 6, no. 4, April 2009 (2009-04-01), pages 228 - 35
MA ET AL., INFLAMM BOWEL DIS., vol. 16, no. 6, June 2010 (2010-06-01), pages 1040 - 50
PETERSON ET AL., EUR J PHARMACOL., vol. 662, no. 1-3, 15 July 2011 (2011-07-15), pages 47 - 54
VIDELA ET AL., J PHARMACOL EXP THER., vol. 316, no. 2, February 2006 (2006-02-01), pages 940 - 5
INOUE ET AL., BIOL PHARM BULL, vol. 34, no. 11, 2011, pages 1659 - 65
HAYDONT ET AL., CLIN CANCER RES., vol. 13, 15 September 2007 (2007-09-15), pages 5331 - 40
G. P. MOSS: "Biochemical Nomenclature and Related Documents", 1992, PORTLAND PRESS, pages: 247 - 251
MARCUCCI; LEFOULON, DRUG DISCOV TODAY, vol. 9, no. 5, 1 March 2004 (2004-03-01), pages 219 - 28
TORCHILIN, EUR J PHARM SCI., vol. 11, no. 2, October 2000 (2000-10-01), pages 81 - 91
ZHAO; LEE, ADV DRUG DELIV REV., vol. 56, no. 8, 2004, pages 1193 - 204
TEMMING ET AL., DRUG RESIST UPDAT., vol. 8, no. 6, 2005, pages 381 - 402
"RNAi Experimental Protocol", 2004, YODOSHA, article "Experimental Medicine Special Edition"
"RNAi Experimental Frequently Asked Questions", 2006, YODOSHA
"Experimental Medicine Special", 2004, YODOSHA
HYOJ; YAKUZAIGAKU ET AL.: "Standard Pharmaceutics", 2003, NANKODO
PIZARRO ET AL., TRENDS MOL MED., vol. 9, no. 5, May 2003 (2003-05-01), pages 218 - 22
MATSUMOTO, GUT, vol. 43, no. 1, July 1998 (1998-07-01), pages 71 - 8
KOSIEWICZ ET AL., J CLIN INVEST., vol. 107, no. 6, March 2001 (2001-03-01), pages 695 - 702
KAWANO ET AL., BLOOD, vol. 101, no. 2, 15 January 2003 (2003-01-15), pages 532 - 40
LEE ET AL., J CELL PHYSIOL., vol. 223, no. 3, June 2010 (2010-06-01), pages 648 - 57
NAGATSUMA ET AL., LIVER INT., vol. 29, no. 1, January 2009 (2009-01-01), pages 47 - 54
BEAVEN SW. ET AL., GASTROENTEROLOGY, vol. 140, no. 3, March 2011 (2011-03-01), pages 1052 - 62
See also references of EP 2781225A4
YOSHIRO NIITSU: "Treatment of Organ Fibrosis by siRNAHSP47", IBN SEMINAR SERIES: TREATMENT OF ORGAN FIBROSIS BY SIRNAHSP47, 2010, JAPAN, XP055146428, Retrieved from the Internet
YOSHIRO NIITSU: "Zoki Sen'isho Chiryo no Shintenkai", THE JOURNAL OF THE JAPANESE RESPIRATORY SOCIETY 1343-3490, vol. 47, no. SUPPL., 2009, pages 67, XP008172636
KIDD, M. ET AL.: "CTGF, intestinal stellate cells and carcinoid fibrogenesis", WORLD J GASTROENTEROL, vol. 13, no. 39, 2007, pages 5208 - 16, XP055144306
HIROSHI NAGANUMA ET AL.: "Shocho Kanmaku yori Hassei shi, Shinkeikei eno Bunka o Shimeshita Akusei Ichokangai Kanshitsu Shuyo no Ichirei", SENDAI SHIRITSU BYOIN IGAKU ZASSHI, vol. 27, 25 June 2007 (2007-06-25), pages 51 - 57, XP008172822, Retrieved from the Internet
KOJI KUBOTA ET AL.: "A Case of Gastrointestinal Stromal Tumor of the Mesentery", JAPANESE JOURNAL OF GASTROENTEROLOGICAL SURGERY, vol. 41, no. 4, 1 April 2008 (2008-04-01), pages 435 - 440, XP055144318, Retrieved from the Internet
SAWAKO YOSHIOKA ET AL.: "Identification of stellate cells in the mouse small intestine", DAI 32 KAI ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN, 11 December 2009 (2009-12-11), pages 240, XP008172820
SAWAKO YOSHIOKA ET AL.: "Isolation of intermediate stellate cells in the mouse small intestine", DAI 33 KAI ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN, 10 December 2010 (2010-12-10), XP008172637
RIEDER; FIOCCHI, NAT REV GASTROENTEROL HEPATOL., vol. 6, no. 4, April 2009 (2009-04-01), pages 228 - 35
MA ET AL., INFLAMM BOWEL DIS., vol. 16, no. 6, June 2010 (2010-06-01), pages 1040 - 50
PETERSON ET AL., EUR J PHARMACOL., vol. 662, no. 1-3, 15 July 2011 (2011-07-15), pages 47 - 54
VIDELA ET AL., J PHARMACOL EXP THER., vol. 316, no. 2, February 2006 (2006-02-01), pages 940 - 5
INOUE ET AL., BIOL PHARM BULL, vol. 34, no. 11, 2011, pages 1659 - 65
HAYDONT ET AL., CLIN CANCER RES., vol. 13, 15 September 2007 (2007-09-15), pages 5331 - 40
G. P. MOSS: "Biochemical Nomenclature and Related Documents", 1992, PORTLAND PRESS, pages: 247 - 251
MARCUCCI; LEFOULON, DRUG DISCOV TODAY, vol. 9, no. 5, 1 March 2004 (2004-03-01), pages 219 - 28
TORCHILIN, EUR J PHARM SCI., vol. 11, no. 2, October 2000 (2000-10-01), pages 81 - 91
ZHAO; LEE, ADV DRUG DELIV REV., vol. 56, no. 8, 2004, pages 1193 - 204
TEMMING ET AL., DRUG RESIST UPDAT., vol. 8, no. 6, 2005, pages 381 - 402
"RNAi Experimental Protocol", 2004, YODOSHA, article "Experimental Medicine Special Edition"
"RNAi Experimental Frequently Asked Questions", 2006, YODOSHA
"Experimental Medicine Special", 2004, YODOSHA
HYOJ; YAKUZAIGAKU ET AL.: "Standard Pharmaceutics", 2003, NANKODO
PIZARRO ET AL., TRENDS MOL MED., vol. 9, no. 5, May 2003 (2003-05-01), pages 218 - 22
MATSUMOTO, GUT, vol. 43, no. 1, July 1998 (1998-07-01), pages 71 - 8
KOSIEWICZ ET AL., J CLIN INVEST., vol. 107, no. 6, March 2001 (2001-03-01), pages 695 - 702
KAWANO ET AL., BLOOD, vol. 101, no. 2, 15 January 2003 (2003-01-15), pages 532 - 40
LEE ET AL., J CELL PHYSIOL., vol. 223, no. 3, June 2010 (2010-06-01), pages 648 - 57
NAGATSUMA ET AL., LIVER INT., vol. 29, no. 1, January 2009 (2009-01-01), pages 47 - 54
BEAVEN SW. ET AL., GASTROENTEROLOGY, vol. 140, no. 3, March 2011 (2011-03-01), pages 1052 - 62
See also references of EP 2781225A4
Attorney, Agent or Firm:
MITSUHASHI, Motoki et al. (JP)
Mihashi 規樹 (JP)
Mihashi 規樹 (JP)
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Claims: