Title:
INTESTINAL FLORA IMPROVEMENT AGENT
Document Type and Number:
WIPO Patent Application WO/2017/142080
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an intestinal flora improvement agent that can improve intestinal flora, using an enzyme to cause beneficial bacteria such as lactobacillales and bifidobacteria to increase in number. A protease that comprises a polypeptide of an amino acid sequence indicated by SEQ ID NO: 1 causes beneficial bacteria such as lactobacillales and bifidobacteria to increase in number in the intestine, and demonstrates a superior intestinal flora improvement effect.
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Inventors:
KURODA MANABU (JP)
YAMAGUCHI SHOTARO (JP)
KATO NORIHISA (JP)
YAMAGUCHI SHOTARO (JP)
KATO NORIHISA (JP)
Application Number:
PCT/JP2017/005986
Publication Date:
August 24, 2017
Filing Date:
February 17, 2017
Export Citation:
Assignee:
AMANO ENZYME INC (JP)
UNIV HIROSHIMA (JP)
UNIV HIROSHIMA (JP)
International Classes:
A61K38/46; A23L2/52; A23L33/10; A61K36/062; A61P1/00; A61P1/10; C12N9/50
Domestic Patent References:
WO2012022745A1 | 2012-02-23 | |||
WO2016071989A1 | 2016-05-12 |
Foreign References:
JP2010004760A | 2010-01-14 | |||
JP2012188372A | 2012-10-04 |
Other References:
GOMI KATSUYA ET AL.: "Cloning and Nucleotide Sequence of the Acid Protease-encoding Gene (pepA) from Aspergillus oryzae", BIOSCI. BIOTECH. BIOCHEM., vol. 57, no. 7, 1993, pages 1095 - 1100, XP055410188
YUKAKO OKAZAKI, ET AL: "3L-02a: Neisseria gonorrhoeae - Tease supplemented diet on rat intestinal environment®", DAI 68 KAI THE JAPANESE SOCIETY OF NUTRITION AND FOOD SCIENCE TAIKAI KOEN YOSHISHU, 30 April 2014 (2014-04-30), pages 286, XP009515243
See also references of EP 3417872A4
YUKAKO OKAZAKI, ET AL: "3L-02a: Neisseria gonorrhoeae - Tease supplemented diet on rat intestinal environment®", DAI 68 KAI THE JAPANESE SOCIETY OF NUTRITION AND FOOD SCIENCE TAIKAI KOEN YOSHISHU, 30 April 2014 (2014-04-30), pages 286, XP009515243
See also references of EP 3417872A4
Attorney, Agent or Firm:
TANAKA, Junya et al. (JP)
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