Title:
INTESTINAL METAGENOMIC FEATURE AS SELECTION MARKER OF CURATIVE EFFECT OF ACARBOSE FOR TREATING TYPE 2 DIABETES
Document Type and Number:
WIPO Patent Application WO/2017/071018
Kind Code:
A1
Abstract:
An intestinal metagenomic feature as a selection marker of curative effect of acarbose for treating type-2 diabetes. The intestinal micro-organic metagenomic feature is a bacteroid intestinal pattern. By using the intestinal pattern concept for the first time, it was found that type 2 diabetic patients with different intestinal parasitic bacterial flora had remarkably different responses to treatment with the diabetic hypoglycemic drug acarbose, and therefore before the drug is used, the intestinal patterns of the patients can be distinguished to select those patients likely to experience an optimal curative effect, and to determine whether acarbose is suitable for treatment of individual patients with type 2 diabetes. In addition, while intestinal patterns are conventionally distinguished through DNA sequencing or PCT amplification of parasitic bacteria in excrement, the intestinal patterns can be well distinguished using a bile acid composition, especially secondary bile acid, under baseline conditions. The intestinal patterns can be identified through markers in blood, and then be used as markers for diagnosis.
Inventors:
NING GUANG (CN)
ZHANG DONGYA (CN)
WANG WEIQING (CN)
WANG XIAOKAI (CN)
GU YANYUN (CN)
FENG QIANG (CN)
LIU RUIXIN (CN)
XU XIAOQIANG (CN)
ZHANG DONGYA (CN)
WANG WEIQING (CN)
WANG XIAOKAI (CN)
GU YANYUN (CN)
FENG QIANG (CN)
LIU RUIXIN (CN)
XU XIAOQIANG (CN)
Application Number:
PCT/CN2015/097566
Publication Date:
May 04, 2017
Filing Date:
December 16, 2015
Export Citation:
Assignee:
SHANGHAI INST FOR ENDOCRINE AND METABOLIC DISEASES (CN)
BGI SHENZHEN (CN)
BGI SHENZHEN (CN)
International Classes:
C12Q1/68; C12Q1/04; C12R1/01
Domestic Patent References:
| WO2008076696A2 | 2008-06-26 |
Foreign References:
| CN104540962A | 2015-04-22 | |||
| CN104603283A | 2015-05-06 | |||
| CN104726596A | 2015-06-24 | |||
| CN102477460A | 2012-05-30 |
Other References:
SI , WEN: "Effects of Acarbose on Serums IL -4, IL -6 and IL -10 of Patients with Type 2 Diabetes", CHINA MASTER'S S THESES FULL-TEXT DATABASE, 15 June 2012 (2012-06-15), pages 5 - 7, XP009502949
See also references of EP 3301185A4
See also references of EP 3301185A4
Attorney, Agent or Firm:
SHANGHAI BRIDGE INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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