Title:
INTRACELLULAR DELIVERY OF BIOMOLECULES TO MODIFY IMMUNE RESPONSE
Document Type and Number:
WIPO Patent Application WO/2019/178006
Kind Code:
A3
Abstract:
The present application provides T cells comprising an antigen and an adjuvant, methods of manufacturing such T cells, and methods of using such T cells, such as for modulating an immune response in an individual.
Inventors:
LOUGHHEAD SCOTT (US)
TALARICO LEEANN (US)
VICENTE-SUAREZ ALFONSO (US)
BOOTY MATT (US)
BERNSTEIN HOWARD (US)
BLAGOVIC KATARINA (US)
SHAREI ARMON R (US)
HLAVATY KELAN (US)
TALARICO LEEANN (US)
VICENTE-SUAREZ ALFONSO (US)
BOOTY MATT (US)
BERNSTEIN HOWARD (US)
BLAGOVIC KATARINA (US)
SHAREI ARMON R (US)
HLAVATY KELAN (US)
Application Number:
PCT/US2019/021705
Publication Date:
November 07, 2019
Filing Date:
March 11, 2019
Export Citation:
Assignee:
SQZ BIOTECHNOLOGIES CO (US)
International Classes:
A61K39/00; A61K39/12
Domestic Patent References:
| WO2016070136A1 | 2016-05-06 | |||
| WO2005060993A1 | 2005-07-07 |
Other References:
ANJUM S. KAKA ET AL: "Genetic Modification of T Cells With IL-21 Enhances Antigen Presentation and Generation of Central Memory Tumor-specific Cytotoxic T-lymphocytes :", JOURNAL OF IMMUNOTHERAPY, vol. 32, no. 7, 1 September 2009 (2009-09-01), US, pages 726 - 736, XP055595375, ISSN: 1524-9557, DOI: 10.1097/CJI.0b013e3181ad4071
KRINA PATEL ET AL: "Combination Immunotherapy with NY-ESO-1-Specific CAR+ T Cells with T-Cell Vaccine Improves Anti-Myeloma Effect | Blood Journal", BLOOD, vol. 128, no. 22, 1 December 2016 (2016-12-01), pages 3366 - 3366, XP055596043
DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; 1 November 2017 (2017-11-01), TALARICO L A ET AL: "Engineered antigen presenting T cells for the treatment of solid tumor cancers", XP002792109, Database accession no. EMB-619371158
LI JINYU ET AL: "The combination ofPleurotus ferulaewater extract and CpG-ODN enhances the immune responses and antitumor efficacy of HPV peptides pulsed dendritic cell-based vaccine", VACCINE, ELSEVIER, AMSTERDAM, NL, vol. 34, no. 31, 19 May 2016 (2016-05-19), pages 3568 - 3575, XP029605515, ISSN: 0264-410X, DOI: 10.1016/J.VACCINE.2016.05.022
GEMMA G KENTER ET AL: "Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia", THE NEW ENGLAND JOURNAL OF MEDICINE, - NEJM -, MASSACHUSETTS MEDICAL SOCIETY, US, vol. 361, no. 19, 5 November 2009 (2009-11-05), pages 1838 - 1847, XP008157144, ISSN: 0028-4793, DOI: 10.1056/NEJMOA0810097
G G KENTER ET AL: "Supplementary to Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia", 5 November 2009 (2009-11-05), pages 1 - 4, XP055629060, Retrieved from the Internet [retrieved on 20191004]
LEEANN TALARICO ET AL: "Engineered antigen presenting T cells for treatment of solid tumor cancers", PROCEEDINGS OF THE AACR SPECIAL CONFERENCE ON TUMOR IMMUNOLOGY AND IMMUNOTHERAPY, 1 September 2018 (2018-09-01), XP055595759, DOI: 10.1158/2326-6074.TUMIMM17-A61
KRINA PATEL ET AL: "Combination Immunotherapy with NY-ESO-1-Specific CAR+ T Cells with T-Cell Vaccine Improves Anti-Myeloma Effect | Blood Journal", BLOOD, vol. 128, no. 22, 1 December 2016 (2016-12-01), pages 3366 - 3366, XP055596043
DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; 1 November 2017 (2017-11-01), TALARICO L A ET AL: "Engineered antigen presenting T cells for the treatment of solid tumor cancers", XP002792109, Database accession no. EMB-619371158
LI JINYU ET AL: "The combination ofPleurotus ferulaewater extract and CpG-ODN enhances the immune responses and antitumor efficacy of HPV peptides pulsed dendritic cell-based vaccine", VACCINE, ELSEVIER, AMSTERDAM, NL, vol. 34, no. 31, 19 May 2016 (2016-05-19), pages 3568 - 3575, XP029605515, ISSN: 0264-410X, DOI: 10.1016/J.VACCINE.2016.05.022
GEMMA G KENTER ET AL: "Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia", THE NEW ENGLAND JOURNAL OF MEDICINE, - NEJM -, MASSACHUSETTS MEDICAL SOCIETY, US, vol. 361, no. 19, 5 November 2009 (2009-11-05), pages 1838 - 1847, XP008157144, ISSN: 0028-4793, DOI: 10.1056/NEJMOA0810097
G G KENTER ET AL: "Supplementary to Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia", 5 November 2009 (2009-11-05), pages 1 - 4, XP055629060, Retrieved from the Internet
LEEANN TALARICO ET AL: "Engineered antigen presenting T cells for treatment of solid tumor cancers", PROCEEDINGS OF THE AACR SPECIAL CONFERENCE ON TUMOR IMMUNOLOGY AND IMMUNOTHERAPY, 1 September 2018 (2018-09-01), XP055595759, DOI: 10.1158/2326-6074.TUMIMM17-A61
Attorney, Agent or Firm:
DONAHUE, Brian et al. (US)
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