Title:
INTRACELLULAR DELIVERY PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2021/020462
Kind Code:
A1
Abstract:
The present disclosure provides a peptide complex that includes a segment X having a prescribed amino acid sequence and a membrane-damaging segment Z.
Inventors:
FUTAKI SHIROH (JP)
ARAFILES JAN VINCENT (JP)
AKISHIBA MISAO (JP)
ARAFILES JAN VINCENT (JP)
AKISHIBA MISAO (JP)
Application Number:
PCT/JP2020/029120
Publication Date:
February 04, 2021
Filing Date:
July 29, 2020
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
A61K31/7088; A61K45/00; A61K38/02; A61K47/64; A61K48/00; C07K16/24; C07K19/00; C12N15/19
Domestic Patent References:
| WO2016076347A1 | 2016-05-19 | |||
| WO2016052442A1 | 2016-04-07 | |||
| WO2018174158A1 | 2018-09-27 | |||
| WO2018027164A1 | 2018-02-08 |
Foreign References:
| RU2522810C1 | 2014-07-20 |
Other References:
OH JI-SEON, PARK MINAH, KIM JUNG-SUK, JANG JAE-HYUNG: "Enhanced cellular transfection by ternary non-viral gene Vectors coupled with adeno-associated virus-derived peptides", MACROMOLECULAR BIOSCIENCE, vol. 14, no. 1, January 2014 (2014-01-01), pages 121 - 130, XP055788001, DOI: 10.1002/mabi.201300296
ARAFILES JAN VINCENT V., HIROSE HISAAKI, AKISHIBA MISAO, TSUJI SHOGO, IMANISHI MIKI, FUTAKI SHIROH: "Stimulating Macropinocytosis for Intracellular Nucleic Acid and Protein Delivery: A Combined Strategy with Membrane- Lytic Peptides To Facilitate Endosomal Escape", BIOCONJUGATE CHEMISTRY, vol. 31, no. 3, 4 February 2020 (2020-02-04), pages 547 - 553, XP055788002, DOI: 10.1021/acs.bioconjchem.0c00064
ARAFILES JAN VINCENT V., HIROSE HISAAKI, AKISHIBA MISAO, TSUJI SHOGO, IMANISHI MIKI, FUTAKI SHIROH: "Stimulating Macropinocytosis for Intracellular Nucleic Acid and Protein Delivery: A Combined Strategy with Membrane- Lytic Peptides To Facilitate Endosomal Escape", BIOCONJUGATE CHEMISTRY, vol. 31, no. 3, 4 February 2020 (2020-02-04), pages 547 - 553, XP055788002, DOI: 10.1021/acs.bioconjchem.0c00064
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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