Title:
INTRACELLULAR SUBSTANCE TRANSPORT SYSTEM AND USAGE OF SAME
Document Type and Number:
WIPO Patent Application WO/2019/208820
Kind Code:
A1
Abstract:
The present invention relates to: a complex that includes (1) nanoparticles, (2) an enzyme inhibitor–containing group represented by formula (A), (3) a ligand-containing group represented by general formula (L1) and supported by the surfaces of the nanoparticles, and (4) a phospholipid-mimicking substance group represented by general formula (B) and supported by the surface of the nanoparticles; and an anti-cancer agent that contains this complex as an active constituent. In general formula (A), R10 is an enzyme inhibitor–containing site, and in general formula (L1), R20 includes a ligand site that binds to a cell surface receptor. In general formulae (A), (L1), and (B), the –S– terminal is a nanoparticle supporting site. The present invention provides: a means for transporting a medical agent to which a ligand has bonded into a cell so that the medical agent can be released within the cell without the medical agent taken into the cell being quickly recycled to the outside of a cell membrane; a means for delivering the medical agent, such as an active substance, to an enzyme within the cell membrane through the use of the means for transporting the medical agent; and an anti-cancer agent that utilizes the means for delivering the medical agent.
More Like This:
| WO/2009/136186 | SURFACES WITH IMMOBILIZED ENZYMES OR ANTI-ICING PROTEINS |
| WO/2014/026271 | SURFACE CHEMICAL GRADIENTS |
| WO/2013/038158 | INTRACELLULAR CELL SELECTION |
Inventors:
NISHIMURA SHIN-ICHIRO (JP)
Application Number:
PCT/JP2019/018094
Publication Date:
October 31, 2019
Filing Date:
April 26, 2019
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
C07K17/14; A61K9/14; A61K31/44; A61K45/00; A61K47/51; A61K47/52; A61K47/54; A61K47/62; A61K47/69; A61P1/04; A61P1/16; A61P1/18; A61P9/00; A61P11/00; A61P13/08; A61P13/12; A61P15/00; A61P35/00; A61P43/00; B82Y5/00; B82Y40/00
Domestic Patent References:
| WO2017131242A1 | 2017-08-03 |
Foreign References:
| JP2012517447A | 2012-08-02 | |||
| JP2013049710A | 2013-03-14 |
Other References:
LEMPENS, E. H. M. ET AL.: "Dendrimer display of tumor-homing peptides", BIOCONJUGATE CHEMISTRY, vol. 22, 2011, pages 397 - 405, XP055652297
WANG, C.-F. ET AL.: "Copper-free azide-alkyne cycloaddition of targeting peptides to porous silicon nanoparticles for intracellular drug uptake", BIOMATERIALS, vol. 35, 2014, pages 1257 - 1266, XP028787930, DOI: 10.1016/j.biomaterials.2013.10.065
ZHANG, J. ET AL.: "iRGD decorated lipid-polymer hybrid nanoparticles for targeted co-delivery of doxorubicin and sorafenib to enhance anti-hepatocellular carcinoma efficacy", NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY, AND MEDICINE, vol. 12, 2016, pages 1303 - 1311, XP029559770, DOI: 10.1016/j.nano.2016.01.017
WANG, C.-F. ET AL.: "Copper-free azide-alkyne cycloaddition of targeting peptides to porous silicon nanoparticles for intracellular drug uptake", BIOMATERIALS, vol. 35, 2014, pages 1257 - 1266, XP028787930, DOI: 10.1016/j.biomaterials.2013.10.065
ZHANG, J. ET AL.: "iRGD decorated lipid-polymer hybrid nanoparticles for targeted co-delivery of doxorubicin and sorafenib to enhance anti-hepatocellular carcinoma efficacy", NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY, AND MEDICINE, vol. 12, 2016, pages 1303 - 1311, XP029559770, DOI: 10.1016/j.nano.2016.01.017
Attorney, Agent or Firm:
SIKS & CO. (JP)
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