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Title:
INTRACEREBRAL OXIDATION INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2008/050754
Kind Code:
A1
Abstract:
Disclosed is an intracerebral oxidation inhibitor which can prevent the occurrence of dementia and is effective for early treatment. Specifically disclosed are: an intracerebral oxidation inhibitor comprising a peptide composed of Leu and Ile or a modified form thereof as an active ingredient; and a prophylactic or therapeutic agent for dementia, which comprises a peptide composed of Leu and Ile or a modified form thereof as an active ingredient and has an inhibitory activity on intracerebral oxidation.

Inventors:
NITTA ATSUMI (JP)
NABESHIMA TOSHITAKA (JP)
Application Number:
PCT/JP2007/070628
Publication Date:
May 02, 2008
Filing Date:
October 23, 2007
Export Citation:
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Assignee:
UNIV NAGOYA NAT UNIV CORP (JP)
KYOWA HAKKO KOGYO KK (JP)
NITTA ATSUMI (JP)
NABESHIMA TOSHITAKA (JP)
International Classes:
A61K38/00; A23L1/305; A61P25/28; A61P39/06
Domestic Patent References:
WO2006090555A12006-08-31
Foreign References:
JP2006096747A2006-04-13
JP2005041834A2005-02-17
JPH0222232A1990-01-25
JP2005532264A2005-10-27
Other References:
FURUKAWA Y. ET AL.: "Shinkei Eiyo Inshi no Sansei Yudo ni yoru No no Hogo. Kino Saiken", vol. 6, no. 1, 2003, pages 87 - 93
NODA Y. ET AL.: "Kochihoyaku Kaihatsu no Genjo to Shorai Tenbo 2003", KAGAKU KOGYO, vol. 54, no. 9, 2003, pages 713 - 723
GRUNDMAN M. ET AL.: "Antioxidant strategies for Alzheimer's disease", PROCEEDINGS OF NUTRITION SOCIETY, vol. 61, no. 2, 2002, pages 191 - 202, XP002644228, DOI: doi:10.1079/PNS2002146
BUTTERFIELD D.A. ET AL.: "Nutritional approaches to combat oxidative stress in Alzheimer's disease", THE JOURNAL OF NUTRITIONAL BIOCHEMISTRY, vol. 13, no. 8, 2002, pages 444 - 461
GILGUN-SHERKI Y. ET AL.: "Oxidative stress induced-neurodegenerative diseases: The need for antioxidants that penetrate the blood brain barrier", NEUROPHARMACOLOGY, vol. 40, no. 8, 2001, pages 959 - 975, XP008160065, DOI: doi:10.1016/S0028-3908(01)00019-3
Attorney, Agent or Firm:
HIRAKI, Yusuke et al. (3-20 Toranomon 4-chome, Minato-ku Tokyo 01, JP)
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