Title:
INTRADERMAL FORMULATION FOR REGENERATIVE MEDICINE
Document Type and Number:
WIPO Patent Application WO/2016/158756
Kind Code:
A1
Abstract:
Provided are: an intradermal formulation for regenerative medicine for performing a treatment to safely, simply, and reliably induce and mature the regeneration or rebirth of lymph vessels, blood vessels, or granulation in conditions such as lymphedema, for which there was no effective method of treatment, and skin ulcers, skin pressure ulcers, and skin damage occurring during lower leg ischemia; and an intradermal administration device for regenerative medicine. The intradermal formulation for regenerative medicine is a formulation to be administered intradermally, the intradermal formulation containing platelet-rich plasma and a growth factor released from at least one type of stem cell selected from adipose-derived stem cells, myeloid stem cells, blood stem cells, and induced pluripotent stem cells. The intradermal administration device (1) for regenerative medicine has a drug chamber (14) for housing an intradermal formulation (15) for regenerative medicine, and a needle (24) and/or cannula for administering the intradermal formulation (15) for regenerative medicine.
Inventors:
TANAKA TETSUO (JP)
HIRAHARA ICHIRO (JP)
IWASE YOICHIRO (JP)
KOIWAI KAZUNORI (JP)
HIRAHARA ICHIRO (JP)
IWASE YOICHIRO (JP)
KOIWAI KAZUNORI (JP)
Application Number:
PCT/JP2016/059633
Publication Date:
October 06, 2016
Filing Date:
March 25, 2016
Export Citation:
Assignee:
TERUMO CORP (JP)
International Classes:
A61K38/18; A61K35/15; A61K35/16; A61K35/19; A61K35/28; A61K35/545; A61P7/10; A61P17/00; A61P17/02
Domestic Patent References:
| WO2013065017A2 | 2013-05-10 | |||
| WO2013046867A1 | 2013-04-04 | |||
| WO2013046868A1 | 2013-04-04 |
Other References:
KENJI KUSUMOTO: "Treatment of chronic ulcers applying platelet-rich plasma (PRP", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 237, no. 1, 2 April 2011 (2011-04-02), pages 141 - 145, ISSN: 0039-2359
JIANG D ET AL.: "The effect of adipose tissue derived MSCs delivered by a chemically defined carrier on full-thickness cutaneous wound healing", BIOMATERIALS, vol. 34, no. 10, pages 2501 - 2515, XP055315716, ISSN: 0142-9612
MAHARLOOEI MK ET AL.: "Adipose tissue derived mesenchymal stem cell (AD-MSC) promotes skin wound healing in diabetic rats", DIABETES RESEARCH AND CLINICAL PRACTICE, vol. 93, no. 2, 31 May 2011 (2011-05-31), pages 228 - 234, XP028260761, ISSN: 0168-8227
YUDAI NISHINO: "Skin regenerative therapy to apply growth factors from stem cell", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 239, no. 8, 19 November 2011 (2011-11-19), pages 851 - 854, ISSN: 0039-2359
KUNIHISA TSUKADA: "Wakatta! Nichijo Shinryo no Kihon Koza Hitome de Wakaru! Saiketsu no Shikata·Chusha no Shikata no Kihon to Chuiten", RESIDENT NOTE, vol. 6, no. 2, May 2004 (2004-05-01), pages 139 - 149, ISSN: 1344-6746
TOYSERKANI MM ET AL.: "Stem cells snow promising results for lymphoedema treatment-a literature review", JOURNAL OF PLASTIC SURGERY AND HAND SURGERY, vol. 49, no. 2, pages 65 - 71, ISSN: 2000-6764
JIANG D ET AL.: "The effect of adipose tissue derived MSCs delivered by a chemically defined carrier on full-thickness cutaneous wound healing", BIOMATERIALS, vol. 34, no. 10, pages 2501 - 2515, XP055315716, ISSN: 0142-9612
MAHARLOOEI MK ET AL.: "Adipose tissue derived mesenchymal stem cell (AD-MSC) promotes skin wound healing in diabetic rats", DIABETES RESEARCH AND CLINICAL PRACTICE, vol. 93, no. 2, 31 May 2011 (2011-05-31), pages 228 - 234, XP028260761, ISSN: 0168-8227
YUDAI NISHINO: "Skin regenerative therapy to apply growth factors from stem cell", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 239, no. 8, 19 November 2011 (2011-11-19), pages 851 - 854, ISSN: 0039-2359
KUNIHISA TSUKADA: "Wakatta! Nichijo Shinryo no Kihon Koza Hitome de Wakaru! Saiketsu no Shikata·Chusha no Shikata no Kihon to Chuiten", RESIDENT NOTE, vol. 6, no. 2, May 2004 (2004-05-01), pages 139 - 149, ISSN: 1344-6746
TOYSERKANI MM ET AL.: "Stem cells snow promising results for lymphoedema treatment-a literature review", JOURNAL OF PLASTIC SURGERY AND HAND SURGERY, vol. 49, no. 2, pages 65 - 71, ISSN: 2000-6764
Attorney, Agent or Firm:
SHINKYU PARTNERS P. C. (JP)
Patent business corporation 眞久 patent firm (JP)
Patent business corporation 眞久 patent firm (JP)
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